Words similar to hotspots

Example sentences for: hotspots

How can you use “hotspots” in a sentence? Here are some example sentences to help you improve your vocabulary:

Previous work has shown that a significant percentage of mutations in p53 and K- ras 2 are localized to mutational hotspots, namely codons 175, 245, 248, 249, 273, and 282 in p53 and codons 12, 13, and 61 in K- ras 2 [reviewed in [ 14 17 18 ] ]. Each of these mutational hotspots was sequenced in the genomic DNA of various pancreatic cell lines using polony technology as follows.
However the contrast in linkage patterns between humans and our closest relatives suggests that recombination hotspots can evolve fairly quickly.
Of particular importance to this study are the genes p53 and K- ras 2 since a significant proportion of the mutations are localized to a relatively small number of mutational hotspots [ 13 14 15 16 ] . In this paper we introduce a screen to detect the presence of pancreatic cancer by looking for somatic mutations in p53 and K- ras 2 using polony technology to microsequence mutational hotspots within these two genes.
Using a similar approach, we recently reported on the subdivision of the ligand binding domain on the insulin receptor into two separate and non-overlapping hotspots with different biological activities [ 3 ] .
Recombination hotspots are local regions of chromosomes, on the order of one or two thousand base pairs of DNA (or less—their length is difficult to measure), in which recombination events tend to be concentrated.