Words similar to hotspots

Example sentences for: hotspots

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Connecting these ideas about the evolution of recombination modifiers to the question of recombination hotspots, we come to the possibility that individual hotspots may have arisen as a byproduct of linkage disequilibrium between genes on either side of the hotspot that were under selection.
This result suggests the possibility of hotspots for gene transposition in the Drosophila genome.
For population geneticists, much of the interest in recombination hotspots comes from their possible effect on the patterns of DNA sequence variation along human chromosomes and from the possibility that these patterns could be used to map the position of alleles that cause disease.
This technology has also been successfully used for known protein targets, such as the insulin receptor [ 3 ] and TNF-β [ 38 ] as well as non-protein targets such as disease-specific RNAs [ 38 ] . We have also shown that the HSPL libraries identify hotspots on novel genes of unknown function and identify functional interaction pathways (manuscript in preparation).
As appealing as the recombination modifier theory of recombination hotspots may be, there is circumstantial evidence that argues against it and that suggests that recombination hotspots are not directly the byproduct of selection on alleles in linkage disequilibrium.