Example sentences for: hotspot

How can you use “hotspot” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • They report that chimpanzees do not have a recombination hotspot in the TAP2 region where humans have a fairly well characterized recombination hotspot (Jeffreys and Neumann 2002).

  • The H2-Eb1 gene contains a recombination hotspot, which has a predominant role in generating different recombinants through meiotic crossing-over within the I region of the mouse major histocompatibility complex (MHC) [ 24].

  • All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.

  • In addition, the biological data suggests that KcD11 binds to a hotspot that can be further separated from KcF12, KcF6 and KcC7.

  • For each position within a mutational hotspot to be genotyped, 20 μL of master mix was combined with 1 μL of genomic DNA as well as 0.23 μL of each the forward and reverse primers (50 μM each; see Table 1) designed to polony amplify the portion of the exon bearing the mutational hotspot(s).


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