Example sentences for: hotspot

How can you use “hotspot” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Initially, each exon bearing a mutational hotspot was individually PCR amplified in a polyacrylamide gel giving rise to one polymerase colony, or polony, per copy of genomic p53 or K- ras 2 DNA.

  • For each position within a mutational hotspot to be genotyped, 20 μL of master mix was combined with 1 μL of genomic DNA as well as 0.23 μL of each the forward and reverse primers (50 μM each; see Table 1) designed to polony amplify the portion of the exon bearing the mutational hotspot(s).

  • Connecting these ideas about the evolution of recombination modifiers to the question of recombination hotspots, we come to the possibility that individual hotspots may have arisen as a byproduct of linkage disequilibrium between genes on either side of the hotspot that were under selection.

  • All of the peptides were competed by both TNFα and TNFβ implying they recognized a hotspot that mapped either within or at least overlapping the ligand-binding domain of TNFR2.

  • The HSPLs KcC7, KcD11, KcF6 but not KcF12 were also inhibited by the neutralizing antibody mAb226 suggesting the 20 mers but not KcF12 interact with a hotspot overlapping with the one recognized by antibody.


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