Words similar to homeobox
Example sentences for: homeobox
How can you use “homeobox” in a sentence? Here are some example sentences to help you improve your vocabulary:
Vertebrate HB genes are divided into two classes: Class I genes (HOX genes) are organized into four clusters (HOX A, B, C, D) with a total of 39 members [ 8 ] . Members of Class II are also called divergent genes, including genes such as PAX, MSX, IRX, and DLX, named after their homologs in Drosophila (paired, muscle segment, Iroquois, and distal-less, respectively) [ 9 10 ] . Accumulating evidence suggests that homeobox genes are important in malignant transformation.
Previously, we generated transgenic mice that overexpress the homeobox transcription factor Hoxc-8 in the thoracic region, where Hoxc-8 is normally expressed ( [ 1 ] and unpublished results).
According to our analysis, homeobox proteins are involved in the regulation of or are regulated by many protein families such as GPCRs, ion channels, tyrosine phosphatases, nuclear hormone receptors, and protein kinases.
We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.
An important type of transcription factor contains a conserved region of 60 amino acids called the homeodomain (HD), encoded by a DNA region, the homeobox (HB).
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