Example sentences for: hif-

How can you use “hif-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, hypoxia-mediated HIF-1α responses are also linked to the regulation of mitochondrial dysfunction through the formation of excessive reactive oxygen species in mitochondria.

  • Another approach that addresses the involvement of multiple factors in therapeutic angiogenesis is the use of a so-called 'master switch gene' of angiogenesis, such as HIF-1α [ 52].

  • 2004), a key role for HIF-1α in mediating exercise-induced gene regulatory responses of glycolytic enzymes is revealed.

  • Ablation of HIF-1α in skeletal muscle was associated with an increase in the activity of rate-limiting enzymes of the mitochondria, indicating that the citric acid cycle and increased fatty acid oxidation may be compensating for decreased flow through the glycolytic pathway in these animals.

  • An inhibitory effect of USF on Myc-mediated cellular proliferation has been demonstrated in HeLa cells [ 33 ] , and a non-canonical HLH element inhibits expression of the fibroblast growth factor binding protein (FGF-BP) in several carcinoma cells [ 34 ] . Furthermore, USF2 inhibits binding of hypoxia-inducible factor-1 (HIF-1) to the plasminogen activator inhibitor -1 (PAI-1) gene in hepatocytes in order to disturb transcriptional activation [ 35 ] . Our results add C/EBPβ-mediated activation of RIIβ to the mechanisms inhibited by USF.


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