Words similar to hif-

Example sentences for: hif-

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A subsequent study, demonstrating an age-dependent reduction in HIF-1α activity, provides one explanation for the lower VEGF-A expression in response to hypoxia in aged animals [ 28].
An inhibitory effect of USF on Myc-mediated cellular proliferation has been demonstrated in HeLa cells [ 33 ] , and a non-canonical HLH element inhibits expression of the fibroblast growth factor binding protein (FGF-BP) in several carcinoma cells [ 34 ] . Furthermore, USF2 inhibits binding of hypoxia-inducible factor-1 (HIF-1) to the plasminogen activator inhibitor -1 (PAI-1) gene in hepatocytes in order to disturb transcriptional activation [ 35 ] . Our results add C/EBPβ-mediated activation of RIIβ to the mechanisms inhibited by USF.
Another approach that addresses the involvement of multiple factors in therapeutic angiogenesis is the use of a so-called 'master switch gene' of angiogenesis, such as HIF-1α [ 52].
Ablation of HIF-1α in skeletal muscle was associated with an increase in the activity of rate-limiting enzymes of the mitochondria, indicating that the citric acid cycle and increased fatty acid oxidation may be compensating for decreased flow through the glycolytic pathway in these animals.
Delivery of intracellular modulators for therapeutic angiogenesis, including transcription factors that control angiogenesis such as hypoxia inducible factor-1 alpha (HIF-1α), is only possible through gene therapy.