Words similar to hic
Example sentences for: hic
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We found that methylation of HIC1 , APC , and BRACA1 genes was more common in AC while CDH1 promoter methylation was seen only in SCC.
Figure 1clearly illustrates the anticipated correlation between initial and final HIC and, therefore, the importance of controlling for initial hepatic iron load in comparative analyses.
Such differences in the two major histologies have also been reported previously for DAPK , HIC1 , and APC genes [ 13 ] . However, we found CDH1 promoter methylation restricted to SCC in the present study, while Dong et al found methylation in both histological types [ 13 ] . This difference may be due to small number of AC patients we studied.
Of these, 15 genes ( MGMT , RASSF1A , APC , RARB , CDH1 , MLH1 , TIMP3 , GSTP1 , DAPK , CDKN2A , p14 ARF , BRCA1 , FHIT , TP73 , and HIC1 ) had previously been shown to be commonly methylated in various solid tumor types [ 4 ] . Six additional genes ( RB1 , NME1 , NME2 , BTG1 , NEDD1 , and APAF1 ) were studied because of their possible involvement in genetic alterations in GCT as indicated by LOH studies [ 8 9 10 ] . The RB1 gene at 13q14.
2% of CC [ 13 ] . HIC1 is a zinc finger transcription factor that is transcriptionally silenced by promoter methylation in several types of human cancer [ 26 ] . Heterozygous Hic1 mouse with promoter methylation of wild type allele develop carcinomas, sarcomas and lymphomas, suggesting that this gene acts as a tumor suppressor gene [ 27 ] . HIC1 gene was down regulated in majority of the CC cell lines examined by us and this down-regulated expression was reactivated upon treatment with demethylating and HDAC-inhibiting agents.
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