Words similar to hexameric
Example sentences for: hexameric
How can you use “hexameric” in a sentence? Here are some example sentences to help you improve your vocabulary:
The essentially complete retention of the M-domain and the hexameric assembly of protomers in the AAA domain emphasizes the critical importance of these domains to the proper functioning of midasin.
To determine the percentage of total cellular myosin-II, the following assumptions were used to calculate the total amount of myosin-II in a cell: total protein concentration in D. discoideum is 50 μg/10 6cells [ 37 ] , myosin-II represents about 1% of the cell's protein [ 38 39 ] , the relative molecular mass of a hexameric "monomer" (two each of the heavy chain and essential and regulatory light chains) of myosin-II is 557 kDa, and the average size of a D. discoideum cell is about 8 μm in diameter when grown on surfaces.
In both midasin and dynein, the evolutionary fusion of the six AAA protomers into a single polypeptide has permitted the individual protomers in the hexameric assembly to acquire substantial structural and functional specialization.
These critical residues lie close to the γ-phosphate site in other AAA proteins with known structures and they are believed to trigger a change in the angle between the N- and C-subdomains of the protomer upon binding of ATP or dissociation of the γ-phosphate [ 18 ] . Indirect evidence suggests that such a conformational change in one protomer can be communicated to the adjacent protomers and result in a cooperative alteration in the shape of the overall hexameric ring [ 19 ] .
In contrast to their shared structure, the AAA proteins participate in diverse cellular activities, including proteolysis, protein folding and unfolding, membrane trafficking, DNA replication, metal ion metabolism and intracellular motility [ 13 14 15 ] . Recent structural studies have revealed that the protomers of an AAA protein usually oligomerize into ring-shaped hexameric structures that constitute molecular platforms essential to their mode of action.
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