Example sentences for: heptad

How can you use “heptad” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The outer surface of the coiled-coil contains grooves into which three heptad repeat regions from the C-terminal part of the gp41 ectodomain pack, resulting in a stable six-helix bundle [ 42 45 46 47 48 49 50 51 52 53 54 ] . The six-helix bundle structure can be detected by specific antibodies [ 14 20 43 55 ] .

  • Coiled-coil domains are protein oligomerization motifs, which consist of two or more alpha helices that twist around one another to form a supercoil [ 1 ] . Peptides with the capacity to form coiled coils are characterized by a heptad repeat pattern in which residues in the first and fourth position are hydrophobic, and residues in the fifth and seventh position are predominantly charged or polar.

  • The absence of any consistent pattern of heptad hydrophobic repeats indicates that there is little or no α-helical coiled-coil structure in the domain.

  • The binding site consists of four highly conserved contiguous heptad repeats which are predicted to form a tight α-helical coiled-coil interaction with the heptad repeat-containing N-terminus of the light chain.

  • The principal changes are the substitution of either tyrosine or phenylalanine for leucine at the beginning of the third heptad repeat and the addition of a second proline adjacent to the first in the second heptad repeat.


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