Words similar to heptamer
Example sentences for: heptamer
How can you use “heptamer” in a sentence? Here are some example sentences to help you improve your vocabulary:
We had previously shown by methylation interference analysis that KRC/ZAS-C bound specifically to the sequence TGTGG within the context of the canonical RSS heptamer plus the immediately flanking guanine [ 14 ] . Because the pentamer motif for KRC/ZAS-C predicted by MEME completely matched with the empirical results, we conclude that the two pentameric motifs discovered by MEME are likely authentic binding sites for KRC/ZAS-N as well.
These data suggest that with respect to the RSS canonical elements, KRC/ZAS-N binds the nonamer more efficiently while KRC/ZAS-C binds the heptamer more efficiently, and that two KRC molecules may be needed to bind a single RSS element.
For example a copy of GGTTT and its complement can form a sequence GG(N 5-6 )CC, fulfilling the minimal DNA binding requirement for the ZAS proteins other than a lack of the 5' guanine [ 25 ] . Similarly, the GT-rich RSS nonamer and the palindromic RSS heptamer can serve as binding sites of KRC.
Because the pentameric motifs derived from the KRC/ZAS-N dataset more closely resemble the canonical RSS nonamer and the motif derived from the KRC/ZAS-C dataset more closely resemble the canonical RSS heptamer and a canonical sequence was derived from the majority of sequences, we propose that the ZAS-N domain of KRC binds RSS nonamers more frequently than the ZAS-C domain, and vice versa for the RSS heptamer in vivo .
These are the spacer, especially the nonamer-proximal half, and the positions of the heptamer and nonamer that are adjacent to the spacer (Figure 1b).
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