Words similar to heptamer
Example sentences for: heptamer
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With respect to the heptamer (canonical sequence: CACAGTG), the CAC sequence bordering the recombination site is the most conserved segment of the sequence [ 32 ] , and mutation of these nucleotides has been found to decrease V(D)J joining in transfection assays using recombination substrates [ 40 ] . Because the sequence of the canonical RSS heptamer is palindrome, we speculate that the TGTG sequence may be sufficient for KRC/ZAS-C binding.
The CA dinucleotide at positions 1 and 2 of the heptamer is required for rearrangement [ 46, 52, 68].
The mouse TCR αchain J gene segments (TCRAJ) and the human Igκ light chain genes (IgVκ) were analyzed, taking advantage of the fact that both loci have been sequenced and the location and sequence of their RSSs have been characterized [ 45 46 ] . Of the 97 IgVκ gene segments listed, 42 (43%) have a nonamer, a heptamer or both matching a sequence within the datasets (Figure 15).
The protections are consistent with the proposal that NarL-phosphate recognizes and binds at multiple heptamer recognition sites within the dmsA P1 promoter region.
We had previously shown by methylation interference analysis that KRC/ZAS-C bound specifically to the sequence TGTGG within the context of the canonical RSS heptamer plus the immediately flanking guanine [ 14 ] . Because the pentamer motif for KRC/ZAS-C predicted by MEME completely matched with the empirical results, we conclude that the two pentameric motifs discovered by MEME are likely authentic binding sites for KRC/ZAS-N as well.
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