Words similar to heptamer
Example sentences for: heptamer
How can you use “heptamer” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, we were able to align the κB motif, the Sb sequence, the RSS nonamer, and part of the RSS heptamer "TGTG" with both PSSMs (Figs.
Subsequently, sequence analysis identified KRC as a member of the ZAS family of proteins which share the ability to bind κB-like motifs [ 15 ] . DNA competition analysis showed that KRC fusion proteins containing the ZAS-C domain bind specifically to both the RSS and to the κB motif [ 14 28 ] . DNA footprinting analysis further showed that KRC/ZAS-C binds to specific nucleotides within the κB and the heptamer of the RSS [ 14 ] . In this study, using a PCR-based DNA-binding site-selection and amplification procedure, we demonstrated that both the N-terminal ZAS-N and the C-terminal ZAS-C domains are able to bind GT-rich DNA sequences, and confirmed that the RSS and κB motifs are the high-affinity targets of KRC.
The patterns of nucleotide diversity at individual positions are similar for both 12- and 23-RSS: the initial CAC of the heptamer is invariant, the remaining four positions of the heptamer are moderately diverse, the spacer is highly diverse, and the A tract of the nonamer (positions 5 through 7) is better conserved than the other nonamer positions (Figure 1a).
Using the ZAS-N- and ZAS-C-selected DNA sequences as input, the MEME program discovered motifs containing sequences similar to the κB or Sb transcriptional enhancer motifs as well as the conserved heptamer or nonamer elements of the RSS.
These data suggest that with respect to the RSS canonical elements, KRC/ZAS-N binds the nonamer more efficiently while KRC/ZAS-C binds the heptamer more efficiently, and that two KRC molecules may be needed to bind a single RSS element.
Loading...