Words similar to gstp
Example sentences for: gstp
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We examined the status of promoter hypermethylation of 16 genes ( CDH1 , DAPK , RARB , HIC1 , FHIT , RASSF1A , APC , CDKN2A , MGMT , BRCA1 , TP73 , TIMP3 , GSTP1 , MLH1 , p14 ARF , and RB1 ) in eight specimens of normal cervical squamous epithelia and 90 CC specimens.
Kinase pathways, particularly those involving ERK and JNK, are suggested to have prominent roles in regulation of proliferation pathways in a variety of cell lines [ 11 12 13 ] . Reduced expression of GSTP1-1 in the resistant cells provides a plausible link with the JNK and ERK regulation pathways in the resistant cells.
1%; RASSF1A , 10%; APC , 10%; CDKN2A , 8.9%; MGMT , 6.7%; BRCA1 , 5.6%; TP73 , 2.2%; TIMP3 , 1.1%; GSTP1 , 1.1%; and MLH1 , 1.1% (Table 1).
The primers used for amplification of methylated and unmethylated promoters of genes RARB , TIMP3 , CDKN2A , p14 ARF , MGMT , DAPK , CDH1 , GSTP1 , APC promoter 1A, RB1 , MLH1 , TP73 , BRCA1 , FHIT , and HIC1 have been described previously http://pathology2.jhu.edu/pancreas/prim0425.htm#MSP; [ 32 47 48 49 ] . Methylated (MF and MR) and unmethylated (UF and UR) primers for RASSF1A promoter were designed according to Herman et al [ 46 ] and as described earlier [ 50 ] . PCR products were run on 2% agarose gels and visualized after ethidium bromide staining.
Of these, 15 genes ( MGMT , RASSF1A , APC , RARB , CDH1 , MLH1 , TIMP3 , GSTP1 , DAPK , CDKN2A , p14 ARF , BRCA1 , FHIT , TP73 , and HIC1 ) had previously been shown to be commonly methylated in various solid tumor types [ 4 ] . Six additional genes ( RB1 , NME1 , NME2 , BTG1 , NEDD1 , and APAF1 ) were studied because of their possible involvement in genetic alterations in GCT as indicated by LOH studies [ 8 9 10 ] . The RB1 gene at 13q14.
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