Words similar to gstp
Example sentences for: gstp
How can you use “gstp” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of these, 15 genes ( MGMT , RASSF1A , APC , RARB , CDH1 , MLH1 , TIMP3 , GSTP1 , DAPK , CDKN2A , p14 ARF , BRCA1 , FHIT , TP73 , and HIC1 ) had previously been shown to be commonly methylated in various solid tumor types [ 4 ] . Six additional genes ( RB1 , NME1 , NME2 , BTG1 , NEDD1 , and APAF1 ) were studied because of their possible involvement in genetic alterations in GCT as indicated by LOH studies [ 8 9 10 ] . The RB1 gene at 13q14.
In addition, expression of GSTP1-1 was reduced in the HL60/TLK286 cell line, which was consistent with a previous study [ 7 ] . Quantitative RT-PCR confirmed the results of ADGE microarray for eleven of thirteen genes.
In addition, GSTP1-1 acts as a negative regulator of JNK primarily through direct protein:protein interactions [ 9 10 ] . These data suggest that GSTP1-1 has a role in regulation of kinase activities and cell proliferation [ 8 11 12 13 ] . Because of this available background information, the HL60 wild type and TLK286 resistant cell lines were chosen as model systems for analysis by ADGE microarray.
Although the interaction among GSTP1-1 and genes of proliferation and kinase pathways needs to be verified and the roles of other differential genes in the TLK286 resistant cell line need further investigation, the expression pattern generated with ADGE microarray provides a blueprint for designing further experiments.
The gene expression profile for the resistant cells revealed with ADGE microarray reflected changes in the expression of GSTP1-1 and genes related to kinase and proliferation pathways.
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