Words similar to gnrh-stimulated

Example sentences for: gnrh-stimulated

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The initial experiments were performed to confirm our earlier finding that RGS3 suppressed GnRH-stimulated IP 3 production in COS-1 cells [ 9 ] and to test a truncated form of RGS3, RGS3T (RGS3 314-519) [ 24 ] for suppressive activity in the same assay (Fig.
Another experiment conducted to test the specificity and molecular locus of RGS3 action in inhibiting GnRH-stimulated LH secretion was treatment of adeno-RGS3 infected cells with an agent that increases intracellular calcium (Fig.
A near-universal feature of cell signaling via seven transmembrane, G protein-coupled receptors is attenuation of a cellular response upon prolonged exposure to an extracellular stimulus [ 1 ] . This desensitization process is well-established for GnRH-stimulated LH secretion from pituitary gonadotropes [ 2 3 ] , and occurs after about 6 h of continued exposure to GnRH in rats [ 3 ] ; removal of GnRH permits recovery from the profound suppression of LH secretion, albeit rather slowly (2-4 days; 4).
Because of the evidence that the signal transduction pathway for GnRH in gonadotropes involves the GnRH receptor, Gqα, phospholipase Cβ, and cellular IP 3 release [ 39 40 ] , we determined the effect of RGS3 on GnRH-stimulated LH secretion using adenoviral-mediated gene transfer in rat pituitary cells (Fig.
The profound inhibition of GnRH-stimulated LH secretion observed in Fig.