Words similar to gnrh-stimulated

Example sentences for: gnrh-stimulated

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5are consistent with this conclusion: adeno-RGS3 infection of rat pituitary cells profoundly suppressed GnRH-stimulated 3H-inositol phosphate accumulation.
GnRH-stimulated LH secretion
Moreover, our finding that GnRH-stimulated IP 3 production was inhibited supports the locus of the RGS3 effect as residing at phospholipase C or earlier in the transduction pathway, most likely at the Gα protein because of our studies both earlier [ 9 ] and here showing that RGS3 binds Gqα in vitro.
Because of the evidence that the signal transduction pathway for GnRH in gonadotropes involves the GnRH receptor, Gqα, phospholipase Cβ, and cellular IP 3 release [ 39 40 ] , we determined the effect of RGS3 on GnRH-stimulated LH secretion using adenoviral-mediated gene transfer in rat pituitary cells (Fig.
A near-universal feature of cell signaling via seven transmembrane, G protein-coupled receptors is attenuation of a cellular response upon prolonged exposure to an extracellular stimulus [ 1 ] . This desensitization process is well-established for GnRH-stimulated LH secretion from pituitary gonadotropes [ 2 3 ] , and occurs after about 6 h of continued exposure to GnRH in rats [ 3 ] ; removal of GnRH permits recovery from the profound suppression of LH secretion, albeit rather slowly (2-4 days; 4).