Words similar to gnrh-stimulated

Example sentences for: gnrh-stimulated

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Because of the evidence that the signal transduction pathway for GnRH in gonadotropes involves the GnRH receptor, Gqα, phospholipase Cβ, and cellular IP 3 release [ 39 40 ] , we determined the effect of RGS3 on GnRH-stimulated LH secretion using adenoviral-mediated gene transfer in rat pituitary cells (Fig.
The initial experiments were performed to confirm our earlier finding that RGS3 suppressed GnRH-stimulated IP 3 production in COS-1 cells [ 9 ] and to test a truncated form of RGS3, RGS3T (RGS3 314-519) [ 24 ] for suppressive activity in the same assay (Fig.
Another experiment conducted to test the specificity and molecular locus of RGS3 action in inhibiting GnRH-stimulated LH secretion was treatment of adeno-RGS3 infected cells with an agent that increases intracellular calcium (Fig.
Moreover, our finding that GnRH-stimulated IP 3 production was inhibited supports the locus of the RGS3 effect as residing at phospholipase C or earlier in the transduction pathway, most likely at the Gα protein because of our studies both earlier [ 9 ] and here showing that RGS3 binds Gqα in vitro.
3, top panel) and as a control for the effects of adeno-RGS3 on GnRH-stimulated LH secretion (Fig.