Words similar to gnrh
Example sentences for: gnrh
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Two molecular loci recently have been implicated as potential modulators of GnRH receptor signaling: one is the receptor itself [ 23 ] , and the other is the G protein that transduces the signal generated by binding of the receptor to its agonist [ 9 ] . With respect to the former locus, G protein coupled receptor kinases (GRKs) act in an agonist-specific manner to phosphorylate intracellular regions of the receptor thus permitting β arrestin binding that sterically inhibits G protein association with the receptor [ 1 45 ] . We have reported previously that experimental expression of GRKs in GnRH receptor-expressing heterologous cells (COS-1) suppressed GnRH-stimulated IP 3 production, and that co-expression of GRK2 and β-arrestin 2 suppressed GnRH receptor signaling more than that of either alone [ 23 ] . Stronger evidence that the GRK/β arrestin paradigm may play a role in regulating GnRH receptor signaling is our recent finding that adenovirus-mediated gene transfer of GRK2 into normal pituitary gonadotropes suppressed GnRH-stimulated LH secretion and IP 3 production [ 31 ] . However, no evidence has been presented for a direct interaction between β-arrestin and the GnRH receptor.
In this case protein-soaked beads were applied prior to GnRH exit (stage 17) and the effects were tested at succeeding stages up to and including their normal exit time (stages 18, 19, 20, 21).
PN-1 immunoreactivity was also present within the basal laminae of the vomeronasal organ, a barrier crossed by GnRH neurons when they initiate their migration.
The first experiments tested whether application of either of these agents over the period of stage 21 to stage 29 affected the initial exit of GnRH neurons from the OE and/or their rate of migration along the ON and into the CNS.
As reagents for the localization of PN-1 in the chick are not available, we examined its localization in the embryonic mouse at the time of GnRH migration.
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