Words similar to glycine
Example sentences for: glycine
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The BTBD proteins belong to the last category, although they are distantly related to kelch proteins (~25% identical over ~250 aa), they lack the residues that are characteristic of kelch repeats, a double glycine sequence and a tyrosine separated from a tryptophan by precisely 6 residues [ 35 37 ] .
Substituting a serine could disrupt this, although a preceding glycine may partially compensate.
The latter has been found for the Glycine Antagonist in Neuroprotection (GAIN) trials, which showed no effect on clinical or MRI surrogate outcomes [ 33, 34].
One type of membrane-localization tag is the myristoyl group, which is attached to the glycine residue of proteins, such as S. cerevisiae Gpa1 (the α subunit of the pheromone-responsive G protein) [ 18 ] , that contain at their N-termini the sequence MGXXXS/T (where "X" can be any amino acid) [ 19 ] . Thus, we investigated whether fusion to the sequence MGCTVS, which is present at the N-terminus of Gpa1 and which we will henceforth refer to as "Myr", could restore function to the mutant versions of Boi1 that are impaired in the ability to bind phospholipid.
The reaction mixtures were incubated on ice in the dark for 2 h, and the biotinylation reaction was terminated by the addition of 100 μl of 9 mM glycine in PBS (pH 7.4).