Words similar to glucocorticoids
Example sentences for: glucocorticoids
How can you use “glucocorticoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.
While fatigue/weakness is not easily treated pharmacologically, some patients respond to glucocorticoids (eg, dexamethasone) [ 70 71 72 ] . While they can be continued until death, the effect may wane after 4 to 6 weeks.
Other mechanisms that may participate in the RU 486-induced inhibition of hepatic apoptosis include the fact that this compound blocks the inhibitory effect of glucocorticoids on suppressors of cytokine signalling in the liver [ 8 ] . This family of proteins is induced by growth hormones and cytokines, and is strongly repressed in vivo by glucocorticoids [ 8 ] . Up-regulation of these proteins by RU 486 [ 8 ] , coupled with significant increase in hepatic TNFα level found in animals treated with RU 486 [ 12 ] , may contribute to the inhibition of apoptosis observed in our study (Fig 1B).
These data suggest that in fasting and insulin-deficient diabetes, as in leptin-deficient ob/ob mice [ 9 19 ] , glucocorticoids dominate leptin and insulin levels in determining AGRP expression, whereas insulin and leptin dominate glucocorticoids in determining hypothalamic POMC expression.
Taken together, these data suggest that elevated glucocorticoids are sufficient to drive the increase in hypothalamic AGRP mRNA during fasting and diabetes but not the reduction in POMC mRNA.
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