Words similar to glucocorticoids
Example sentences for: glucocorticoids
How can you use “glucocorticoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
Several lines of evidence indicate that NF-κB is constitutively activated in cancer cells, suggesting that it plays an important role in tumorigenesis [ 30 ] . Activated glucocorticoid receptors have been shown to repress NF-κB-mediated gene expression [ 31 ] , and to cause a significant reduction in nuclear levels of p65 protein, a subunit of NF-κB [ 31 ] . A variety of mitogens, cytokines, and reactive oxygen intermediates have been shown to rapidly cause the translocation of NF-κB to the nucleus [ 30 31 32 ] , and the ability of dexamethasone to interfere with this translocation is blocked by prior treatment with the glucocorticoid antagonist RU 486 [ 30 ] . Based on these findings, it is plausible to speculate that exposure to RU 486 may interfere with the function of endogenous glucocorticoids as regulators of cell cycle, allowing the initiation and progression of malignant transformation of liver cells.
The glucocorticoids were discontinued at age 9 months but she still gained weight poorly; routine chemistry analyses showed evolving hypercalcemia (outpatient calcium peak 13.
Glucocorticoids (GC's) are the effectors of stress and necessarily impact multiple target tissues during normal function.
Other mechanisms that may participate in the RU 486-induced inhibition of hepatic apoptosis include the fact that this compound blocks the inhibitory effect of glucocorticoids on suppressors of cytokine signalling in the liver [ 8 ] . This family of proteins is induced by growth hormones and cytokines, and is strongly repressed in vivo by glucocorticoids [ 8 ] . Up-regulation of these proteins by RU 486 [ 8 ] , coupled with significant increase in hepatic TNFα level found in animals treated with RU 486 [ 12 ] , may contribute to the inhibition of apoptosis observed in our study (Fig 1B).
Glucocorticoids have previously been reported to increase body weight set point, as determined by hoarding behavior in rats [ 11 ] , while adrenalectomy has been reported to lower body weight set point in rats [ 12 ] . In addition, central infusion of glucocorticoids leads to increases in body weight and food intake with a concomitant induction of hypothalamic NPY [ 13 ] . Nevertheless, it remains unclear if an elevation in glucocorticoid concentration contributes to the effect of fasting on hypothalamic gene expression.
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