Example sentences for: glucocorticoids

How can you use “glucocorticoids” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The further elevation in POMC expression observed after adrenalectomy of the obese mice could plausibly be due to elevated leptin combined with decreased glucocorticoids, since glucocorticoids may antagonize the effects leptin [ 30 ] .

  • The latter is the true catabolic entity, has narrow specificity for tryptophan, and is inducible in the presence of tryptophan, glucocorticoids and heme cofactor [ 17].

  • Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.

  • Glucocorticoids produce a receptor-mediated inhibitory effect on both basal and hormone-stimulated expression of a newly discovered family of molecules known as suppressors of cytokine signalling [ 8 ] . These molecules play an important role in shutting off cytokine action [ 8 ] , and RU486 may therefore augment cytokine-mediated effects.

  • Heterogeneous groups of medications that have unclear mechanisms of action, but uncontested benefits in some patients include glucocorticoids (eg, dexamethasone), cannabinoids (eg, tetrahydrocannabinol), and benzodiazepines (eg, lorazepam) [ 61 62 63 ] .


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