Words similar to glucocorticoids
Example sentences for: glucocorticoids
How can you use “glucocorticoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.
Glucocorticoids (CORT) function through the GR to both activate specific gene expression as well as transrepress NF-κB [ 41 ] . Since GR confers this latter effect by associating through protein-protein interactions with NF-κB bound at κB response elements [ 43 44 45 46 47 ] , it is important to also evaluate changes in GR protein levels (see below).
The further elevation in POMC expression observed after adrenalectomy of the obese mice could plausibly be due to elevated leptin combined with decreased glucocorticoids, since glucocorticoids may antagonize the effects leptin [ 30 ] .
Glucocorticoids (GC's) are the effectors of stress and necessarily impact multiple target tissues during normal function.
Indeed, since tumor necrosis factor alpha (TNFα) is known to suppress hepatic apoptosis [ 9 ] , a function which is considered a safeguard mechanism against neoplasia [ 10 11 ] , the reported ability of RU486 to elevate hepatic TNFα production in vivo and to enhance cell sensitivity to its toxic effects is alarming [ 12 ] . Glucocorticoids also inhibit hepatocellular proliferation [ 13 14 15 ] and modulate the expression of oncogenes and tumor suppressor genes [ 11 ] , via mechanisms involving the glucocorticoid receptor [ 16 17 18 ] , further supporting the notion that inhibiting these receptors may result in harmful effects.
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