Words similar to glucocorticoids
Example sentences for: glucocorticoids
How can you use “glucocorticoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
After more chronic exposure, this delicate balance could plausibly become disrupted, leading to glucocorticoid-mediated development of the metabolic syndrome [ 10 ] . Thus interactions between insulin, leptin, and glucocorticoids, and the neuropeptide responses they generate within the melanocortin system, allow complex metabolic responses to nutritional status but may also allow the development of metabolic pathologies.
The further elevation in POMC expression observed after adrenalectomy of the obese mice could plausibly be due to elevated leptin combined with decreased glucocorticoids, since glucocorticoids may antagonize the effects leptin [ 30 ] .
Glucocorticoids (CORT) function through the GR to both activate specific gene expression as well as transrepress NF-κB [ 41 ] . Since GR confers this latter effect by associating through protein-protein interactions with NF-κB bound at κB response elements [ 43 44 45 46 47 ] , it is important to also evaluate changes in GR protein levels (see below).
Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.
Glucocorticoids produce a receptor-mediated inhibitory effect on both basal and hormone-stimulated expression of a newly discovered family of molecules known as suppressors of cytokine signalling [ 8 ] . These molecules play an important role in shutting off cytokine action [ 8 ] , and RU486 may therefore augment cytokine-mediated effects.
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