Example sentences for: glucocorticoid

How can you use “glucocorticoid” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The inclusions bear a superficial resemblance to those described in some of the polyglutamine disorders, and appear to sequester Hsp70, ubiquitin, importin-β, and glucocorticoid receptor.

  • In the absence of ligand such as androgen, glucocorticoid, progestin, and mineralocorticoid, the SHR maintains a cytosolic inactive state by association with heat shock proteins and/or other proteins such as corepressors.

  • For example, PP5 is a major component of mature glucocorticoid receptor complexes of higher eukaryotes and appears to regulate glucocorticoid receptor function in vivo [ [ 34 ] and references therein].

  • Rab24 contains a unique arginine-rich insert, 126EEDRRRRR 133 [ 25 ] in the domain cognate to loop-8 in H-Ras [ 34 ] . The latter sequence is reminiscent of unusual arginine-rich nuclear localization signals that allow proteins like HIV tet and rev to undergo nuclear translocation by association with importin-β, in the absence of importin-α [ 45 46 ] . Since the loop-8 insert in Rab24 lies adjacent to the conserved N(T)KxD nucleotide binding cassette, we hypothesized that conformational changes caused by the D123I substitution might render the Rab24 mutant capable of disrupting the nuclear import machinery [ 47 ] . To test this possibility, we co-expressed mycRab24wt or mycRab24(D123I) with GR-GFP, a fusion between the glucocorticoid receptor and green fluorescent protein.

  • The programmed cell death gene, PDCD6 , is a member of the family of intracellular Ca2 +-binding proteins and a part of the apoptotic machinery controlled by T-cell receptor (TCR), Fas, and glucocorticoid signals [ 11 17 ] . TERT encodes a reverse transcriptase required for the replication of chromosome termini and plays a role in telomere elongation.


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