Words similar to glucocorticoid
Example sentences for: glucocorticoid
How can you use “glucocorticoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
Chronically elevated cortisol levels caused by Cushing's syndrome leads to central obesity [ 1 ] while the reduction of cortisol caused by Addison's disease leads to decreased body weight [ 2 ] . Obesity in several rodent models is also associated with elevated corticosterone levels, and adrenalectomy reverses some of the phenotypes associated with these forms of obesity [ 3 4 5 6 7 ] . Furthermore, elevated corticosterone production can cause a metabolic syndrome [ 8 ] . These data suggest that reduction of glucocorticoid production might therefore constitute a plausible clinical strategy to treat obesity.
These data raise the possibility that potential anti-obesity drugs based on reducing glucocorticoid tone or elevating melanocortin tone may have limited efficacy in treating forms of obesity in which those systems are not perturbed.
There the GR acts as a ligand-activated transcriptional stimulator or repressor of primary response genes by binding to glucocorticoid hormone-responsive elements (GRE) contained in the promoter regions of steroid-responsive genes and either facilitating or repressing the formation of an active transcriptional complex.
Moreover, it is especially noteworthy that the nearly 2-fold decline of glucocorticoid receptor (GR) (Table 2) is also of very high relative importance in defining SMGs deprived of NF-κB nuclear translocation.
This hypothesis is particularly compelling since recent data suggest that aberrant glucocorticoid activity may play a key role in the development of the metabolic syndrome [ 10 ] .
Loading...