Words similar to glucocorticoid
Example sentences for: glucocorticoid
How can you use “glucocorticoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
Adrenalectomy reverses obese phenotypes including melanocortin tone in mice models of obesity in which plasma glucocorticoid levels are elevated.
In the absence of ligand such as androgen, glucocorticoid, progestin, and mineralocorticoid, the SHR maintains a cytosolic inactive state by association with heat shock proteins and/or other proteins such as corepressors.
Several lines of evidence indicate that NF-κB is constitutively activated in cancer cells, suggesting that it plays an important role in tumorigenesis [ 30 ] . Activated glucocorticoid receptors have been shown to repress NF-κB-mediated gene expression [ 31 ] , and to cause a significant reduction in nuclear levels of p65 protein, a subunit of NF-κB [ 31 ] . A variety of mitogens, cytokines, and reactive oxygen intermediates have been shown to rapidly cause the translocation of NF-κB to the nucleus [ 30 31 32 ] , and the ability of dexamethasone to interfere with this translocation is blocked by prior treatment with the glucocorticoid antagonist RU 486 [ 30 ] . Based on these findings, it is plausible to speculate that exposure to RU 486 may interfere with the function of endogenous glucocorticoids as regulators of cell cycle, allowing the initiation and progression of malignant transformation of liver cells.
For example, PP5 is a major component of mature glucocorticoid receptor complexes of higher eukaryotes and appears to regulate glucocorticoid receptor function in vivo [ [ 34 ] and references therein].
We tested the hypothesis that inhibition of the glucocorticoid receptor will trigger events that may ultimately lead to liver cancer.
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