Words similar to glucocorticoid
Example sentences for: glucocorticoid
How can you use “glucocorticoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
Chronically elevated cortisol levels caused by Cushing's syndrome leads to central obesity [ 1 ] while the reduction of cortisol caused by Addison's disease leads to decreased body weight [ 2 ] . Obesity in several rodent models is also associated with elevated corticosterone levels, and adrenalectomy reverses some of the phenotypes associated with these forms of obesity [ 3 4 5 6 7 ] . Furthermore, elevated corticosterone production can cause a metabolic syndrome [ 8 ] . These data suggest that reduction of glucocorticoid production might therefore constitute a plausible clinical strategy to treat obesity.
Nevertheless, pharmacological antagonism of glucocorticoid (type II) receptor by mifepristone (RU486) was reported to reverse high fat diet-induced obesity [ 14 ] . Since diet-induced obesity does not entail elevated glucocorticoid levels [ 15 16 17 ] , this result suggests that reduction of glucocorticoid levels would reverse obesity even when glucocorticoid levels are not elevated.
In contrast to other models of obesity, however, diet-induced obesity was not associated with either elevated glucocorticoid levels or reduced hypothalamic POMC mRNA.
On the other hand, obesity in humans does not generally entail elevated plasma cortisol [ 9 10 11 12 13 ] and it is not clear how effective reduction of glucocorticoid production would be to reverse obesity if glucocorticoid production were otherwise normal.
Rab24 contains a unique arginine-rich insert, 126EEDRRRRR 133 [ 25 ] in the domain cognate to loop-8 in H-Ras [ 34 ] . The latter sequence is reminiscent of unusual arginine-rich nuclear localization signals that allow proteins like HIV tet and rev to undergo nuclear translocation by association with importin-β, in the absence of importin-α [ 45 46 ] . Since the loop-8 insert in Rab24 lies adjacent to the conserved N(T)KxD nucleotide binding cassette, we hypothesized that conformational changes caused by the D123I substitution might render the Rab24 mutant capable of disrupting the nuclear import machinery [ 47 ] . To test this possibility, we co-expressed mycRab24wt or mycRab24(D123I) with GR-GFP, a fusion between the glucocorticoid receptor and green fluorescent protein.
Loading...