Words similar to gcn

Example sentences for: gcn

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Around 75% of these genes are known to be induced by Gcn4p in response to amino-acid limitation and contain the Gcn4p promoter element [ 34, 35].
In contrast, IfkB begins at the kinase domain and is the only known GCN2-like protein that does not possess a pseudokinase domain.
In yeast and mammalian cells, GCN2 is a protein that senses amino acid starvation and brings about altered cell physiology in response to such starvation [ 24 25 ] . GCN2 is a protein kinase that phosphorylates the α subunit of the translation initiation factor eIF2 [ 26 ] . The GCN2 protein from yeasts, Drosophila , and mammals is composed of three domains: a pseudokinase domain that may function as a regulatory domain, a kinase domain, and a HisRS domain that shares significant similarity to histidyl-tRNA synthetases [ 27 28 29 30 ] . Studies of yeast GCN2 revealed that the HisRS domain binds uncharged tRNAs that accumulate when cells are starved for amino acids [ 31 32 ] . As a result the kinase domain is activated and phosphorylates eIF2α at Ser51.
The mutagenized residues probably are indeed important for the function of this protein, but not because they are part of a GCN5-like acetyltransferase domain, which this protein does not contain.
Thus, the relationship between ATF-2 and the GCN5-like acetyltransferase superfamily seems to be invalid, leaving the structural basis for the reported acetyltransferase activity of ATF-2 an open issue.