Words similar to gcn

Example sentences for: gcn

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Within the amino terminal sequences, yeast and other GCN2 proteins have a degenerate kinase domain of unknown function [ 31 ] . There is a 63 amino acid long sequence in IfkA that has 38% identity to the V and VI subdomains of the IfkA/B kinase domain, indicating the presence of an amino terminal pseudokinase domain in the Dictyostelium protein (fig.
GCN2 of yeast and mammals is a known sensor of amino acid starvation and regulates cellular responses to such starvation [ 24 25 ] . Using degenerate primers and PCR and database searching identified two GCN2-like genes in Dictyostelium , ifkA and ifkB . Thinking that one or both of these genes may play a role in sensing amino acid starvation and in initiating development, we carried out the work described herein to examine their functions.
The mutagenized residues probably are indeed important for the function of this protein, but not because they are part of a GCN5-like acetyltransferase domain, which this protein does not contain.
Although the overall rate of initiation of translation is reduced by eIF2α phosphorylation, the translation of some specific mRNAs is greatly enhanced under these conditions [ 24 25 ] . The characteristic feature of mRNAs whose translation is enhanced by GCN2 phosphorylating eIF2α are several upstream open reading frames (uORF) within the 5' untranslated region (5'UTR) of the mRNAs.
IfkB is unique among GCN2-like proteins in that it does not possess the amino terminal pseudokinase domain.