Example sentences for: gcn

How can you use “gcn” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Using the yeast GCN2 amino acid sequence as a query sequence, searches of the Dictyostelium genomic and cDNA sequence databases revealed two ORFs with significant identity to GCN2 proteins of yeast and mammals.

  • A significant difference between the Ifk kinase domain and yeast GCN2 kinase domain is the length of the insert sequence between subdomain IV and V, which is around 290 amino acids in the Dictyostelium Ifk protein and 110 amino acids in yeast GCN2.

  • We reasoned that a GCN2-like protein might be involved in sensing amino acid starvation in Dictyostelium and in regulating the growth to development transition.

  • Around 75% of these genes are known to be induced by Gcn4p in response to amino-acid limitation and contain the Gcn4p promoter element [ 34, 35].

  • This includes the characteristic features peculiar to the kinase domain of GCN2 proteins, the m1, m2, and m3 motifs of the HisRS domain, and a cluster of positively charged residues at the C-terminus that are thought to function in ribosome binding and dimerization [ 31 37 41 ] . Within the kinase domain, the Dictyostelium proteins possess an inserted sequence between the 4th and 5th kinase subdomains that is also found in this position in all known GCN2-like proteins.


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