Words similar to gcn

Example sentences for: gcn

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Within the amino terminal sequences, yeast and other GCN2 proteins have a degenerate kinase domain of unknown function [ 31 ] . There is a 63 amino acid long sequence in IfkA that has 38% identity to the V and VI subdomains of the IfkA/B kinase domain, indicating the presence of an amino terminal pseudokinase domain in the Dictyostelium protein (fig.
Similar extensions amino terminal to the kinase domain are found in GCN2 proteins from other species, and the function of this portion of the protein is unknown.
We reasoned that a GCN2-like protein might be involved in sensing amino acid starvation in Dictyostelium and in regulating the growth to development transition.
Investigations with yeast GCN2 also suggest that that C-terminus is required for ribosome binding and facilitates GCN2 dimerization and activation [ 33 34 35 ] .
The predicted amino acid sequences of IfkA and IfkB are nearly identical within the kinase domain and the HisRS domain, and in turn these two domains share significant sequence identity with GCN2 proteins from yeast, Drosophila , and mammals.