Words similar to gcn
Example sentences for: gcn
How can you use “gcn” in a sentence? Here are some example sentences to help you improve your vocabulary:
Based on the normal function of GCN2-like proteins [ 25 ] , these findings suggest that uncharged tRNAs are more prevalent within the cells during this time relative to either growing cells or to cells immediately after removal of the food source.
The sequence identity within the HisRS domain of IfkA/B and yeast GCN2 is 28%, with strong conservation within the M1, M2, and M3 motifs that are characteristic of class II aminoacyl-tRNA synthetases [ 37 ] . The similarity between the kinase domains is much higher, with IfkA/B possessing 44% identity with yeast GCN2, with high conservation of all of the kinase subdomains.
The insert in IfkA and IfkB is significantly longer than that of other GCN2 proteins.
Although the overall rate of initiation of translation is reduced by eIF2α phosphorylation, the translation of some specific mRNAs is greatly enhanced under these conditions [ 24 25 ] . The characteristic feature of mRNAs whose translation is enhanced by GCN2 phosphorylating eIF2α are several upstream open reading frames (uORF) within the 5' untranslated region (5'UTR) of the mRNAs.
This is similar to the enhanced translation of certain yeast and mammalian mRNAs (GCN4, ATF4, both transcription factors regulated by GCN2) when GCN2 in these organisms is activated by amino acid starvation, even though bulk mRNA undergoes a decrease in translation efficiency [ 24 25 ] . The hallmark of mRNAs that are upregulated by GCN2 and eIF2α phosphorylation is the presence of several upstream open reading frames within their 5' UTRs.
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