Words similar to furazolidone
Example sentences for: furazolidone
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Both in animal and human studies of heart failure, β-adrenergicblockade intervention appears to have beneficial effects on cardiacmyocyte function [ 1 23 24 ] . Of particularimportance, studies using carvedilol have shown remarkable improvementsin cardiac performance [ 12 13 15 16 ] andreduction in mortality in humans [ 17 ] .We have previously shown that propranolol, a nonselective β-blocker,is cardioprotective and prevents the development of heart failurein turkeys when given concurrently with furazolidone [ 21 ] . Similarly, carteolol, a nonselective β-blocker,resulted in improvement in ejection fraction, reduction in ventricularvolumes, an increase in developed pressure as well as an increasein rate of survival in our turkey model [ 18 ] . Improvementin cardiac function was associated with cellular remodeling of cardiacmyocytes.
Furazolidone was stopped afterday twenty-eight and the animals were randomized into three groups:one group did not receive carvedilol treatment, DCM 0 (n= 52), whereas the other two groups, DCM 1 (n = 19) andDCM 20 (n = 20), were treated with carvedilol in the samedosages as respective aged-matched control animals (see following).Similarly, age matched control animals were randomized into threegroups: one group received no pharmacological agent (Con 0 .n = 13), whereas the other two groups received different dosagesof carvedilol, 1 mg/kg (Con 1 n = 11) or 20 mg/kg bodyweight (Con 20 n = 10).
We have previously shown that removal of furazolidone from thefeed after three weeks results in progressive cardiac dilatationand heart failure [ 18 ] . At the time ofrandomization of the DCM group into three groups i.e., DCM 0 (notreatment), DCM 1 (lower dose carvedilol) or DCM 20 (higherdose carvedilol), fractional shortening was not different betweenthe groups (p > 0.1).
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