Words similar to fibulin-
Example sentences for: fibulin-
How can you use “fibulin-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Laminin is a glycoprotein composed of three chains, A, B1, and B2 in a cross-shaped molecule; this protein is found in basement membranes where it interacts with other such components as collagen IV, heparan-sulfate proteoglycan, and nidogen [ 45 ] . Laminin contains EGF-like modules in the amino-terminal region of the A, B1, and B2 chains [ 45 ] . Surprisingly, these modules do not appear to be involved in the binding of fibulin-1.
Fibulin-1 has been reported to interact with such extracellular matrix proteins as fibronectin, laminin, nidogen, aggrecan and versican [ 39 40 41 42 ] . Fibronectin is a glycoprotein found as multimers in insoluble form in the extracellular matrix.
As explained above, mHB-EGF has been reported to be involved as a structural protein in such tissue developmental processes as wound healing and it is feasible that the direct physical association of mHB-EGF with fibulin-1 may be useful in the tissue remodeling of a wound site and in scar formation.
The site of fibulin-1 binding to laminin maps to the carboxyl-terminal segment of the laminin A chain which consists of five basic tandem repeats containing conserved glycine and cysteine residues [ 39 46 ] . The binding site of laminin to fibulin-1 maps to the calcium-binding type II EGF-like modules of fibulin-1 [ 39 ] .
The interactions of LTBP-3 and fibulin-1C with the extracellular domain of proHB-EGF may provide further insights into the roles that these proteins play in cellular and tissue development processes.
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