Words similar to fibrotic
Example sentences for: fibrotic
How can you use “fibrotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .
Vancheri and collaborators [ 20 ] found that TNF-α-stimulated fibrotic lung fibroblasts had decreased COX-2 expression and PGE 2 production, but they further showed that these findings were a result of decreased expression of TNF-α receptors.
HF-IPF might have been harvested from fibrotic lesions where fibroblasts had previously undergone a greater number of cell divisions than HF-NL, obtained from nonfibrotic lungs.
The synovium from the TGF-β1 virus treated joints was highly fibrotic 17 days after viral injection, with evidence of osteometroplasia found in the synovium (Fig.
[ 21 ] reported that fibrotic lung fibroblasts had decreased COX-2 expression and PGE 2 production in response to TGFβ stimulation.
Loading...