Words similar to fibrotic
Example sentences for: fibrotic
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Vancheri and collaborators [ 20 ] found that TNF-α-stimulated fibrotic lung fibroblasts had decreased COX-2 expression and PGE 2 production, but they further showed that these findings were a result of decreased expression of TNF-α receptors.
In addition, patients with a favorable outcome had larger PPD skin test reactions, higher absolute CD4+ cell counts, lower serum β 2 microglobulin levels, and were more likely to have fibrotic changes on their initial chest x-ray, than subjects with an unfavorable outcome.
Bein et al also found that patients with more severe lung disease (Murrary Lung injury score more than 2.5) did not respond to rotational therapy, whereas those with less severe disease (less than 2.5) had significant changes in P a O 2 /FIO 2 . This can be explained by the changes in ARDS with time, as the lung evolves from a wet, heavy, atelectatic lung to a brittle fibrotic lung [ 12].
The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .
The synovium from the TGF-β1 virus treated joints was highly fibrotic 17 days after viral injection, with evidence of osteometroplasia found in the synovium (Fig.
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