Words similar to fhit
Example sentences for: fhit
How can you use “fhit” in a sentence? Here are some example sentences to help you improve your vocabulary:
His114 corresponds to His98 of Fhit, which was localized in low barrier hydrogen-bonding distance to the α-β bridging oxygen of a bound ApppA analog in co-crystal structure with Fhit His96Asn [ 35].
Presumably, because normal Fhit products are mononucleotides with low p K a values, the enzyme does not have a group to protonate an alkoxide leaving group and thus substitution of carbon for the β phosphorus turns a substrate into an inhibitor.
Derivatives of pentaerythritol, tetrapodal compounds 12,13 and 14, were also evaluated for Fhit inhibition.
An added benefit of these constructions is the availability of yeast strains that possess high levels of dinucleoside polyphosphates and at the same time express a mutant Fhit-homologous protein, because these are conditions which have been postulated to constitute the signaling form of Fhit [ 16 ] . Finally, using controlled genotypes we revisited conditions that lead to increased accumulation of dinucleoside polyphosphates [ 24 25 26 27 28 29 30 31 32 33 ] . Recognizing that hnt2 deletion is a pathological condition, we were particular interested in identifying conditions that lead to accumulation of such compounds in cells that contain a functional HNT2 gene, rather than simply identifying conditions that produce diadenosine polyphosphate accumulation in the absence of Hnt2.
Mutagenesis [ 14 ] , X-ray crystallography [ 16 40 ] , and stereochemical analysis [ 41 ] indicate that His96 is the nucleophile that attacks the α-phosphate of Fhit substrates.
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