Words similar to fhit

Example sentences for: fhit

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Ongoing in vitro studies aim to evaluate the stereochemistry of phosphorothioyl binding to Fhit while in vivo studies test the effects of these compounds on programmed cell death.
4%) have also reported a similar overall high frequency of promoter methylation [ 12 13 ] . We identified promoter methylation in >25% cases in CDH1 , DAPK , and RARB genes, while it was less frequent (10-25% cases) in HIC1 , FHIT , RASSF1A , and APC genes in CC patients.
The primers used for methylated and unmethylated-specific PCR for genes RARB , TIMP3 , CDKN2A , p14 ARF , MGMT , DAPK , CDH1 , GSTP1 , APC promoter 1A, RB1 , MLH1 , TP73 , BRCA1 , FHIT , and HIC1 have been described previously http://pathology2.jhu.edu/pancreas/prim0425.htm#MSP; [ 34 35 36 37 ] . For additional genes, we designed the following gene-specific primers for methylated (MF and MR) and unmethylated (UF and UR) sequences according to Herman et al [ 33 ] :
The phosphorothioate analogs, 5b and 6b, bound approximately 10 and 75 times better to Fhit than 1 . Thus, conservation of bond-lengths between adenylate moieties of 1 , 5 and 6 is conducive to binding Fhit.
Presumably, because normal Fhit products are mononucleotides with low p K a values, the enzyme does not have a group to protonate an alkoxide leaving group and thus substitution of carbon for the β phosphorus turns a substrate into an inhibitor.