Words similar to fhit

Example sentences for: fhit

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We presume that compounds 6b , 12b and 13b with 2, 3 or 4 identical CH 2 -phosphorothioadenosyl groups can present a manganese bound 6b -like complex to Fhit in a similar manner.
On the basis of mutagenesis of the conserved His residues in Fhit [ 39] and the location of these His residues in crystal structures of Hint and Fhit [ 25, 35], a catalytic role was proposed for His114 [ 24].
Ongoing in vitro studies aim to evaluate the stereochemistry of phosphorothioyl binding to Fhit while in vivo studies test the effects of these compounds on programmed cell death.
Inhibitors, at approximately 4,2, 1, 0.5 and 0.25 times K i value, were added to assays of Fhit with ApppBODIPY [ 10 ] . K i values were obtained by calculating the inhibitor concentration-dependence in reduction of k cat / K m (apparent) as earlier described [ 10 ] .
Mutagenesis [ 14 ] , X-ray crystallography [ 16 40 ] , and stereochemical analysis [ 41 ] indicate that His96 is the nucleophile that attacks the α-phosphate of Fhit substrates.