Words similar to factor-α
Example sentences for: factor-α
How can you use “factor-α” in a sentence? Here are some example sentences to help you improve your vocabulary:
With improved cardiac function, there should be a reduction inactivation of the adrenergic-renin-angiotensin axes as well as adecrease in activated cytokines such as tumor-necrosis factor-α.In our model of heart failure, cardiac function correlated withthe incidence of apoptosis.
The PPARγ agonist, 15d-PGJ 2 , functions as a general inhibitor of microglial functions [ 56 57 58 ] . For example, this agent inhibits the expression of inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-1 β and major histocompatibility complex class II in activated microglia.
Chess and coworkers have shown that transforming growth factor-α and hepatocyte growth factor increase the phosphorylation of p44/p42 MAPK in H441 cells [ 23 ] . Epidermal growth factor, which binds to the same receptor as transforming growth factor-α, increases SP-A content in human fetal lung [ 24 ] . Hepatocyte growth factor has also been shown to upregulate the synthesis of SP-A in rat type II cells [ 25 ] . Thus, phosphorylation of p44/42 MAPK may be involved in the up-regulation of SP-A gene expression, results consistent with our observation that inhibition of basal levels of p44/42 MAPK phosphorylation may decrease SP-A gene expression.
Tumour necrosis factor-α blockade reduces synovial expression of CCL2 and CXCL8 and reduces inflammatory cell migration into RA joints [ 9 ] . In addition, these chemokines, produced by RA synovial stromal cells, have been shown to stimulate monocyte migration [ 10 ] . The functional importance of chemokines in joint inflammation has also been established in animal models of RA where antibodies to these mediators significantly reduce both the number of leukocytes recruited and the severity of disease.
ELISA = enzyme-linked immunosorbent assay; IP-10 = interferon-gamma inducible protein 10; mAb = monoclonal antibody; MCP-1 = monocytechemotactic protein-1; MIP = macrophage inflammatory protein; OA = osteoarthritis; PBMC = peripheral blood mononuclear cells; PE = phycoerythrin;RA = rheumatoid arthritis; RANTES = regulated upon activation, normal T cell expressed and secreted; RT-PCR = reverse transcriptase-polymerasechain reaction; SCL = stromal cell line; SRBC = sheep red blood cells; TNF-α = tumor necrosis factor-α.
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