Example sentences for: factor-α

How can you use “factor-α” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For instance, tumor necrosis factor-α (TNF-α) can modify intracellular signal transduction and regulate ionic channel activities in various epithelial cells [ 9 ] . A few studies have shown that cytokines can alter biliary epithelial cell function [ 10 11 ] .

  • MMP-2 differs from several other members of the metalloproteinase family in that its transcription is not induced in response to the proinflammatory cytokines tumor necrosis factor-α and interleukin-1, and seems primarily regulated post-translationally.

  • This is an ADAM10-homolog known to be a tumor necrosis factor-α (TNFα) convertase [ 21 ] , TNFα produced by Kupffer cells in the liver stimulates production of TNFα, a mitogen for hepatocytes helping to generate new cells needed to rebuild damaged areas of the liver [ 22 ] . Kupffer cells have a significant role as mediators of acute inflammation after CCl 4 treatment; however, they also produce factors that can cause secondary injury in the liver through fibrogenic responses.

  • Ghrelin and its receptor are expressed in human T-lymphocytes, where they can inhibit cytokine activation, including interleukins, tumor necrosis factor-α and leptin [18].

  • The PPARγ agonist, 15d-PGJ 2 , functions as a general inhibitor of microglial functions [ 56 57 58 ] . For example, this agent inhibits the expression of inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-1 β and major histocompatibility complex class II in activated microglia.


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