Words similar to estrogens
Example sentences for: estrogens
How can you use “estrogens” in a sentence? Here are some example sentences to help you improve your vocabulary:
Estrogen receptors have been identified in cultured fibroblasts of various origins and vascular smooth muscle cells [ 51 52 53 ] . Estrogens enhance proliferation of fibroblasts and inhibit vascular smooth muscle migration [ 54 55 ] . Binding of estrogens to fibroblasts also stimulates fibroblast interaction with epithelial cells with subsequent acceleration of maturation of epithelial cells [ 56 ] .
While the ER isoforms have contrasting effects on AP-1 activity in the presence of estrogens, ERα truncations that lack the NTD and ERβ both enhance AP-1 activity in the presence of SERMs [ 30 31 ] . Mutational analysis of ERα action at AP-1 sites suggests these effects may be related to N-CoR binding [ 39 ] , and we have proposed that SERM action at AP-1 sites may therefore involve contacts with corepressors [ 31 51 ] . The fact that ERα and ERβ show completely different ligand preferences of interaction with N-CoR suggests that the target for SERM activation at AP-1 sites may not be N-CoR in both cases.
This tendency toward autoimmunity in females is often ascribed to hormonal differences, because in a number of experimental disease models estrogens exacerbated disease, and androgens can inhibit disease activity [ 3, 4].
Recently, much attention has been given to the neuroprotective properties of estrogens for both chronic neurodegenerative diseases and acute insults such as stroke.
Caution may be necessary in the use of estrogens in this population, because estrogens have been associated with a small but real risk of ischemic heart disease and cerebral infarcts [ 26].
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