Words similar to estrogens
Example sentences for: estrogens
How can you use “estrogens” in a sentence? Here are some example sentences to help you improve your vocabulary:
Several active research programs are investigating the risk associated with serum estrogens, gonadotropins and urinary sex hormone metabolites for a variety of diseases including breast cancer [ 1 ] , endometrial cancer [ 2 ] , and osteoporosis [ 3 ] . The results of the few published studies suggest that the natural temporal variability (true variation over time, not variation due to storage or other factors) of some serum estrogens, gonadotropins and urinary sex hormone metabolites is sufficiently great that a single measurement occasion may be inadequate to ensure a reliable estimate [ 4 5 6 ] . Published intraclass correlation coefficients (ICC) vary between 0.06 and 0.62 for estradiol (E 2 ) and between 0.52 and 0.69 for estrone (E 1 ) [ 4 ] . Only the percent of free E 2 and of SHBG-bound E 2 have been found to be sufficiently reliable to account for as much as 50% of the variance in the true mean ( ICC > 0.7).
Other media were phenol red-free DMEM-HG without estrogens (PhR-/E2-), or phenol red-free DMEM-HG with 20 nM E2 (PhR-/E2+).
Since production of placental hormones is characteristic of mature syncytium [ 5 9 11 53 54 ] , which shows in vivo cytoplasmic ERβ expression only, one may also assume that estrogens stimulate production of placental hormones by ST.
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
Finally, SMRT also binds ERβ in the presence of estrogens, but we have not explored the structural features that promote this interaction.
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