Words similar to epitope
Example sentences for: epitope
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In order to verify the expression of the midasin gene as a single polypeptide and to make a preliminary study of its function, we modified the chromosomal MDN1 gene in a diploid strain of yeast by adding an oligonucleotide encoding a hemagglutamin (HA) epitope tag to the 3'-end of one copy of the gene.
The coding region for Xenopus Wnt-5a including the myc epitope tag in pSP64T [ 45 ] was digested with BglII, treated with klenow enzyme and ligated into the retroviral vector PMI-hCD5 [ 46 ] digested with NotI and treated with Klenow enzyme.
The residues K10, the backbone of S11, V12, V12, S14, V17, G40, E55, K63 and 64V, from the kinked carboxy-terminal helix, a beta-turn, and parts of the beta-sheet, define a putative binding epitope (Figure 2b).
In the studies presented here, both α i2 and sα i2 contain an internal EE epitope, as used previously for α i2 [ 11 12 ] . The use of the EE epitope allows the direct comparison of subcellular localization and expression of α i2 and sα i2 , and facilitates immunoprecipitation of the two expressed proteins.
Antigen-specific T cells encounter antigen presented by dendritic cells that migrate to the paracortical regions of draining lymph nodes after initial antigen contact [ 1 ] . Only dendritic cells have the capacity to induce activation in resting peripheral T cells [ 2 3 ] . Once activated, differentiated T helper cells contact antigen-specific B cells and provide signals for B cell differentiation via CD154-CD40 interactions, as well as by the production of cytokines [ 4 5 6 ] . Consistent with this general understanding of the induction of antibody responses to protein immunogens, good antibody responses to synthetic peptide-epitope constructs have been shown to depend on the presence, orientation, and multiplicity of the T cell epitope in the construct [ 7 8 9 10 11 ] . As a confirmation of this finding with synthetic epitope constructs, most protein immunogens studied to date contain multiple T cell epitopes, for example [ 12 13 ] .
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