Words similar to enzyme-bound

Example sentences for: enzyme-bound

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The intracellular concentration of ThDP has been estimated at 30 μM, with only about 7 percent being free cytosolic and the remainder being enzyme-bound with much of this within mitochondria [ 4 5 ] . Previous findings indicate a complex, cell-type dependent regulation of compartmentalization and intracellular pools of thiamine and its phosphorylated derivatives in response to fluctuating extracellular thiamine levels [ 4 5 6 ] . Hence, thiamine transport, including that by mitochondria, is of interest.
Although the estimated concentration, in mice and human cells, of intracellular ThDP is about 30 μM, much of this is found in a low turnover pool representing enzyme-bound ThDP [ 4 17 ] . The estimated concentration of free cytosolic ThDP available for intracellular transport is about 10% of the total concentration and thus 2 to 3 μM [ 4 17 18 ] . Hence the physiological significance of the mitochondrial ThDP uptake just decribed is uncertain.