Words similar to endometrium
Example sentences for: endometrium
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The PTEN gene is also frequently deleted or mutated in a variety of sporadic human malignancies, such as glioblastoma and carcinomas of the prostate, endometrium and breast.
Hybridization reactions that contained the recommended 10 μg of cRNA (from human endometrium adenocarcinoma cells) detected 35% of the 1779 transcripts on the GeneChip ®. Reducing the amount of cRNA in the hybridization to 5 μg reduced the fraction detected to 30%, and further reducing the cRNA to 2.5 μg allowed detection of only 27% of the sequences [ 9 ] . Ohyama et al.
Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.
During follicular selection (mid follicular phase, as determined by endometrium morphology) dominant follicles in human ovaries showed granular cytoplasmic LHR expression in granulosa cells (g, Fig.
In endometrium (late follicular phase - note stromal edema), LHR immunoreactivity was associated with endometrial glands (g, Fig.
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