Words similar to eif
Example sentences for: eif
How can you use “eif” in a sentence? Here are some example sentences to help you improve your vocabulary:
Concomitant with the increased eIF2α phosphorylation in the parental strain was a secondary shift of ribosomes from polysomes to free ribosomes.
As described above, bulk mRNA undergoes a secondary shift from polysomes to free ribosomes in Ax4 cells, and this shift was not seen in BS153 cells as it is dependent upon eIF2α phosphorylation by IfkA.
An interesting note is that the p27 Kip1mRNA has a long 5'-UTR that is 65% GC and is predicted to form stable secondary structures [ 29 ] . Thus, even though it shares these characteristics with the putative "weak" mRNAs that require elevated eIF4E activity for efficient translation, p27 Kip1responds in an opposite manner.
These results indicate that IfkA is normally active from about 1 hour to about 7 hours after starvation and normally phosphorylates eIF2α during this time period (however, we have no direct data that demonstrates IfkA phosphorylates eIF2α).
In yeast and mammalian cells, GCN2 is a protein that senses amino acid starvation and brings about altered cell physiology in response to such starvation [ 24 25 ] . GCN2 is a protein kinase that phosphorylates the α subunit of the translation initiation factor eIF2 [ 26 ] . The GCN2 protein from yeasts, Drosophila , and mammals is composed of three domains: a pseudokinase domain that may function as a regulatory domain, a kinase domain, and a HisRS domain that shares significant similarity to histidyl-tRNA synthetases [ 27 28 29 30 ] . Studies of yeast GCN2 revealed that the HisRS domain binds uncharged tRNAs that accumulate when cells are starved for amino acids [ 31 32 ] . As a result the kinase domain is activated and phosphorylates eIF2α at Ser51.
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