Words similar to eif
Example sentences for: eif
How can you use “eif” in a sentence? Here are some example sentences to help you improve your vocabulary:
Numerous studies have implicated eIF4E in formation and progression of tumors.
These include effects on other translational control proteins including p70 S6 kinase (p70S6K), eIF4G, eIF4B, and eEF2 (reviewed in [ 23 ] ). At present neither the targets that are essential for inhibition of cell proliferation by rapamycin nor the mechanism by which these targets mediate cell cycle arrest are completely understood.
Inhibiting the expression of eIF4E by expressing antisense RNA reverses ras-mediated transformation of cultured cells as indicated by decreased efficiency of growth in soft agar and tumor formation in nude mice [ 20 ] . Similarly, antisense-mediated reduction of eIF4E in breast cancer cells inhibits both their tumorigenic and angiogenic properties [ 21 ] . On the other hand, overexpression of 4EBP reverses transformation mediated by v-src [ 18 ] .
One possibility is that binding of 4EBP-1 to eIF4E releases other initiation factors that are in limited supply but also required for cap-independent initiation.
The p27 Kip1and eIF4E monoclonal antibodies were purchased from Transduction Laboratories.