Words similar to eif
Example sentences for: eif
How can you use “eif” in a sentence? Here are some example sentences to help you improve your vocabulary:
This suggests that normally during early development in the wild type strain, enhanced translation of countin mRNA occurs as a result of IfkA phosphorylating eIF2α.
Thus we have not detected any changes in eIF2α phosphorylation that can be attributable to regulated IfkB activity.
They have long GC-rich 5'-UTRs that can form extensive secondary structure and have been classified as "weak" mRNAs because they are translated inefficiently when eIF4E levels are limiting (reviewed in [ 15 ] ). It has been proposed that when eIF4E levels are elevated these mRNAs can more effectively recruit eIF4E and its associated factors including eIF4G, a scaffold protein essential in recruiting the small ribosomal subunit, and eIF4A, a helicase essential for scanning through secondary structures in the 5'-UTR [ 15 27 ] .
One possible mechanism to account for the decreased initiation rate is phosphorylation of eIF2α.
Overexpression of eIF4E leads to deregulated growth and malignant transformation of a variety of cultured cell lines [ 12 13 14 ] . Moreover, elevated levels of eIF4E are commonly found in solid tumors, especially in breast, colon, and head and neck tumors [ 15 ] . Clinical studies indicate that eIF4E gene amplification and protein overexpression is associated with malignant progression in these tumors [ 16 ] . High eIF4E levels are also associated with a higher rate of cancer recurrence and cancer-related death [ 17 ] . In contrast to eIF4E, overexpression of 4EBP inhibits cell proliferation [ 18 ] and 4EBP-1 expression levels are inversely correlated with the progression of certain types of tumors [ 19 ] .
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