Example sentences for: eif

How can you use “eif” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The fact that multiple surrogates had the TxRLL motif suggests that this region of p170 is necessary and critical for binding of HCV mRNA to eIF3.

  • The data presented here indicate that direct inhibition of eIF4E may be more effective and a more specific means of targeting tumor cells than treatment with rapamycin.

  • The observed decline in cyclin D1 is expected since constitutively active 4EBP should reverse cyclin D1 expression mediated by eIF4E overexpression.

  • Although the overall rate of initiation of translation is reduced by eIF2α phosphorylation, the translation of some specific mRNAs is greatly enhanced under these conditions [ 24 25 ] . The characteristic feature of mRNAs whose translation is enhanced by GCN2 phosphorylating eIF2α are several upstream open reading frames (uORF) within the 5' untranslated region (5'UTR) of the mRNAs.

  • In this process, eIF4E, which functions by binding the 7-methylguanosine cap, is the rate-limiting factor due to its low abundance [ 1 2 ] . In normal cells, elevated eIF4E activity is associated with proliferation and is regulated by multiple mechanisms.


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