Words similar to eif
Example sentences for: eif
How can you use “eif” in a sentence? Here are some example sentences to help you improve your vocabulary:
The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
These newly detected domains included the SUI1 domain, that is found in eIF1 and related proteins [ 78 ] , the third globular domain of DNA gyrase/Topoisomerase II and, most interestingly, a distinct globular domain in the yeast DDRP β' subunit (PDB: 1k83; region 1143-1271).
Thus we have not detected any changes in eIF2α phosphorylation that can be attributable to regulated IfkB activity.
Phosphorylation of 4EBP disrupts its ability to bind eIF4E, freeing eIF4E to bind eIF4G, which functions to recruit additional components of the initiation complex [ 7 8 ] . The net result is that phosphorylation of 4EBP enhances cap-dependent translation initiation.
Database searches using Patternfind at the ISREC server were performed using parameters appropriate for short protein queries and were successful in identifying a human gene product, subunit p170 of eIF3 (Figure 3).
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