Words similar to eif
Example sentences for: eif
How can you use “eif” in a sentence? Here are some example sentences to help you improve your vocabulary:
An interesting note is that the p27 Kip1mRNA has a long 5'-UTR that is 65% GC and is predicted to form stable secondary structures [ 29 ] . Thus, even though it shares these characteristics with the putative "weak" mRNAs that require elevated eIF4E activity for efficient translation, p27 Kip1responds in an opposite manner.
Overexpression of eIF4E leads to deregulated growth and malignant transformation of a variety of cultured cell lines [ 12 13 14 ] . Moreover, elevated levels of eIF4E are commonly found in solid tumors, especially in breast, colon, and head and neck tumors [ 15 ] . Clinical studies indicate that eIF4E gene amplification and protein overexpression is associated with malignant progression in these tumors [ 16 ] . High eIF4E levels are also associated with a higher rate of cancer recurrence and cancer-related death [ 17 ] . In contrast to eIF4E, overexpression of 4EBP inhibits cell proliferation [ 18 ] and 4EBP-1 expression levels are inversely correlated with the progression of certain types of tumors [ 19 ] .
A portion of the cellular eIF4E is imported into the nucleus through a mechanism that requires the protein 4E-T [ 31 ] . In the nucleus eIF4E is localized to specific nuclear bodies and associates with promyelocytic leukemia protein (PML, [ 32 ] ). Nuclear eIF4E appears to be involved in export of cyclin D1 mRNA to the cytosol [ 25 ] . Both 4E-T and PML interact with the same domain of eIF4E that binds 4EBP [ 32 ] . Thus expression of constitutively active 4EBP may block nuclear functions of eIF4E, one consequence being a reduction in cyclin D1 mRNA that can be translated in the cytoplasm.
Interestingly, others have demonstrated that eIF4E has an additional role in the nucleus.
The amino acid sequence of the phosphopeptide used to raise the antibodies (EGMILSEIS*RRRIRSI, * indicates phosphorylated serine) is highly conserved among the eIF2α proteins of all species, including that of Dictyostelium (I at position 8 is a L in Dictyostelium ).
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