Words similar to ectopic
Example sentences for: ectopic
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This could be either from increased Collagen X mRNA transcription within prehypertrophic and hypertrophic cells or from ectopic activation of Collagen X transcription in proliferating chondrocytes.
In in vitro studies, carbenoxolone abolished the generation of full or partial ectopic spike generation, by 4-AP, in the CA 3 region of rat hippocampal slices [ 6 ] . Also carbenoxolone depresses spontaneous epileptiform activity in the CA 1 region of rat hippocampal slices [ 7 ] . Carbenoxolone appears to cross the blood brain barrier about one hour after an intraperitoneal injection in rats as there was the inhibition of 11-β-hydroxysteroid dehydrogenase in multiple brain regions [ 1 ] . It and/or its congener glycyrrehetinic acid may also enter the eyes of humans.
Several of these changes are maladaptive in the sense that they contribute to the generation of the abnormal sensations that constitute neuropathic pain, by producing ectopic spontaneous activity into the CNS, altering synaptic drive, increasing excitability and diminishing inhibitory action in the dorsal horn of the spinal cord, and by making novel synaptic contacts with inappropriate neurons [ 1 4 ] . A number of the injury-regulated genes we describe here may contribute directly to this altered sensory processing; CB1 receptor, VGF, the phospholemman ion channel, SNAP25 A, endothelin-1 and the ligand-gated 5-HT3 receptor (Table 4, see additional file 3).
Considering the inverse correlation between p27 and SKP2 protein levels, we asked whether ectopic SKP2 can forge p27 down-regulation in LNCaP cells.
Constitutive ectopic expression of TAF II135 impairs F9 cell primitive endoderm differentiation
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