Words similar to ectopic

Example sentences for: ectopic

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While our study suggests that SKP2 is an important player in p27 regulation in prostate cancer cells, recent studies have also implicated another protein, CSN5/JAB1, in p27 regulation [ 54 55 ] . CSN5 is a subunit of the COP9/signalosome (CSN) complex [ 56 57 58 59 ] , but also forms distinct complexes apparently lacking CSN subunits [ 55 60 61 62 ] . Overexpression of CSN5 in NIH3T3 cells causes p27 export from the nucleus and ectopic degradation [ 54 ] . Notably, like SKP2 [ 33 36 37 38 ] , CSN5 was found to be overexpressed in cancers devoid of p27 [ 63 ] . However, our studies did not reveal any effect of MIB on CSN5 expression.
This potential role of Wnt-5a as a tumor suppressor is further supported by the evidence that ectopic Wnt-5a in human uroepithelial cells prevents tumorigenesis when injected into athymic nude mice [ 13 ] .
These observations suggest that ectopic TAF II 135 expression promotes T-RA induction of genes which are normally not activated in F9 cells leading to a novel differentiation pathway.
An important consideration at the outset of these studies concerned the possibility that ectopic hCAR expression or adenoviral transduction might affect the normal development and/or function of T cells.
C57mg cells were chosen since they become transformed by ectopic expression of Wnt-1 and by loss of function of Wnt-5a [ 12 15 16 ] . In addition, Wnt-5a/Rfz-2 C57mg cells exhibited phenotypic differences from wt C57mg cells (see results).