Words similar to ectopic
Example sentences for: ectopic
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Previous studies by others had shown that the ectopic expression of PTEN in anchorage-independent tumor cells greatly reduced their ability to grow in soft agar [ 4 5 6 ] . In this latter situation, however, the forced expression of ectopic PTEN effectively impairs cellular proliferation in general, even under two-dimensional culture conditions where the cells are attached to substratum [ 4 6 7 8 9 10 18 33 44 ] . It was therefore difficult to discern from these experiments how effectively and selectively PTEN participates in anchorage-dependent growth control.
The effects are most pronounced in line A cells which express the highest level of ectopic TAF II 135 and do not show a differentiated cell morphology even upon prolonged exposure to T-RA.
Recent studies [ 20, 32] have demonstrated that the synovial tissue of rheumatoid arthritis patients can develop lymphoid aggregates that have the cellular components of an ectopic germinal center and that can sustain B-cell clonal expansion and diversification.
This could be either from increased Collagen X mRNA transcription within prehypertrophic and hypertrophic cells or from ectopic activation of Collagen X transcription in proliferating chondrocytes.
We further show that stable ectopic expression of TAF II 135 in F9 cells delays the targeted degradation of endogenous TAF II 135, TBP, and the RARγ2 in response to T-RA.