Words similar to ectopically
Example sentences for: ectopically
How can you use “ectopically” in a sentence? Here are some example sentences to help you improve your vocabulary:
A detailed understanding of how ectopically expressed TAF II 135 blocks primitive endoderm differentiation will require the identification of novel marker genes whose expression is significantly altered in lines A and B and which may be directly regulated by TAF II 135.
Full-length C/EBPα is absent from the pituitary progenitor GHFT1-5 cell line [ 42 45 ] in which ectopically expressed C/EBPα activates co-transfected growth hormone and prolactin promoters [ 42 44 45 ] . We show here that ectopically expressed C/EBPα prolongs GHFT1-5 cells in the G1 and S phases of the cell cycle in a transcription-independent fashion.
In the lens, alpha-crystallin also associates with type III intermediate filament proteins and the beaded filament proteins CP49 and CP115, and correct beaded filament assembly has been shown depend on the presence of alpha-crystallin [ 16 ] . Beaded filament mRNA levels are greatly increased in differentiating lens epithelium and have been suggested as a pan-specific marker for lens fiber development [ 17 ] . Alpha-crystallin has also been shown to interact directly with DNA [ 18 ] . In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [ 19 ] . A nuclear role for alphaB in the lens was supported by the findings that a subset of lens epithelial cells derived from alphaB knockout mice demonstrated hyperproliferation and genomic instability [ 20 ] . In addition, the administration of exogenous alpha-crystallin to primary bovine lens epithelial cell cultures resulted in the formation of lentoid bodies, consistent with a role for these proteins in lens differentiation [ 21 ] . These findings indicate that alpha-crystallin may have a multitude of in vivo functions.
It is also possible that our construct is expressed ectopically.
Several heat shock proteins have been found in cell nuclei in the absence of stress [ 30 ] , and alpha-crystallin has been shown to interact directly with DNA [ 18 ] . AlphaB, expressed in transfected CHO cells, has been shown to ectopically localize to interphase nuclei, suggesting a regulatory role for this protein in the nucleus [ 19 ] . A subset of immortalized lens epithelial cells from alphaBKO mice have been shown to hyperproliferate [ 20 ] suggesting that alphaB may be important in maintaining genomic stability.
Loading...