Words similar to ectopically
Example sentences for: ectopically
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A detailed understanding of how ectopically expressed TAF II 135 blocks primitive endoderm differentiation will require the identification of novel marker genes whose expression is significantly altered in lines A and B and which may be directly regulated by TAF II 135.
In the lens, alpha-crystallin also associates with type III intermediate filament proteins and the beaded filament proteins CP49 and CP115, and correct beaded filament assembly has been shown depend on the presence of alpha-crystallin [ 16 ] . Beaded filament mRNA levels are greatly increased in differentiating lens epithelium and have been suggested as a pan-specific marker for lens fiber development [ 17 ] . Alpha-crystallin has also been shown to interact directly with DNA [ 18 ] . In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [ 19 ] . A nuclear role for alphaB in the lens was supported by the findings that a subset of lens epithelial cells derived from alphaB knockout mice demonstrated hyperproliferation and genomic instability [ 20 ] . In addition, the administration of exogenous alpha-crystallin to primary bovine lens epithelial cell cultures resulted in the formation of lentoid bodies, consistent with a role for these proteins in lens differentiation [ 21 ] . These findings indicate that alpha-crystallin may have a multitude of in vivo functions.
This result is confirmed by immunoblotting with monoclonal antibody 20TA which detects both the endogenous and ectopically expressed TAF
We first verified whether treatment of these cells with T-RA would lead to the depletion of the ectopically expressed TAF II 135.
In line A, both the ectopically expressed TAF II 135 and the endogenous TAF II 135 were depleted with the same kinetics (Fig.
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