Words similar to ecams
Example sentences for: ecams
How can you use “ecams” in a sentence? Here are some example sentences to help you improve your vocabulary:
MAdCAM-1 (mucosal addressin cell adhesion molecule-1), IL-10 (Interleukin-10), HEV (high endothelial venular), ECAMs (endothelial cell adhesion molecules), IBD (inflammatory bowel diseases), UC (ulcerative colitis), CD (Crohn's disease), ICAM-1 (intracellular adhesion molecule 1), VCAM-1 (vascular adhesion molecule 1), NF-kB (nuclear transfection factor kB), TNF-α (tumor necrosis factor alpha), GM-CSF (granulocyte-macrophage colony-stimulating factor), GCSF (granulocute colony stimulating factor), ECL (enhanced chemiluminescence)
In the setting of IBD, the expression of ECAMs like ICAM-1, VCAM-1, and MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is observed in experimental models of colitis, [ 2 3 4 5 ] and also within the inflamed human colon in Crohn's disease and ulcerative colitis [ 6 7 ] .
There are at least two regulating pathways in ECAM expression, one is a cytokine-dependent pathway which is widely studied and the other is cytokine-independent [ 58 ] . IL-10 apparently prevents cytokine-induced NF-kB binding activity to the ECAM promoter [ 59 ] and blocks the excessive expression of ECAMs in cytokine-mediated inflammatory conditions.
Because of this prime role of TNF-α in IBD, anti-TNF-α antibody therapy has been very successfully used in IBD to reduce both colonic injury and expression of ECAMs in IBD [ 51 ] .
IL-10 deficiency in colitis increases expression of several ECAMs including ICAM-1, VCAM-1 and MAdCAM-1 [ 60 ] . We performed an experiment, where under non-stimulated conditions only 55.
Loading...