Example sentences for: dysregulated

How can you use “dysregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • At the skeletal site of metastatic invasion, the bone metabolism is dysregulated and bone resorption or bone formation, or both, is upregulated.

  • The clinical relevance is emphasized by our previous finding that the expression of GDF-9 is dysregulated in oocytes of women with Polycystic Ovary Syndrome [ 47 ] .

  • The findings presented here, suggesting that different ECM signaling pathways are active in different cancers, could have important clinical implications, as knowledge of the specific pathways dysregulated in a particular cancer may be valuable for devising effective therapy that targets those pathways.

  • Moreover, normal cellular controls on cell-cycle progression appears to be dysregulated by HIV-1 expression because cell-cell contact and differentiation, events that normally lead to the down-regulation of cyclin D 1 expression [ 25 ] , did not significantly alter cyclin D 1 protein levels in HIV-1 infected podocytes.

  • In rodents, resistin is derived exclusively from adipocytes [11,12], circulates at increased levels in obese animals [11], and causes dysregulated hepatic glucose production, leading to insulin resistance [13,14].


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