Example sentences for: dysregulated

How can you use “dysregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Tyrosine kinase activity is tightly regulated in normal cells, but is dysregulated due to mutation in some cancers, including lung cancer, resulting in enhanced proliferation and survival of cancer cells.

  • The clinical relevance is emphasized by our previous finding that the expression of GDF-9 is dysregulated in oocytes of women with Polycystic Ovary Syndrome [ 47 ] .

  • Although K562 cells are derived from leukemia, among the genes showing altered regulation were several that are also dysregulated in breast cancer, including c- myc and cyclin D2; their altered expression was verified by real-time PCR.

  • Moreover, normal cellular controls on cell-cycle progression appears to be dysregulated by HIV-1 expression because cell-cell contact and differentiation, events that normally lead to the down-regulation of cyclin D 1 expression [ 25 ] , did not significantly alter cyclin D 1 protein levels in HIV-1 infected podocytes.

  • At the skeletal site of metastatic invasion, the bone metabolism is dysregulated and bone resorption or bone formation, or both, is upregulated.

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