Example sentences for: dysregulated

How can you use “dysregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The findings presented here, suggesting that different ECM signaling pathways are active in different cancers, could have important clinical implications, as knowledge of the specific pathways dysregulated in a particular cancer may be valuable for devising effective therapy that targets those pathways.

  • At the skeletal site of metastatic invasion, the bone metabolism is dysregulated and bone resorption or bone formation, or both, is upregulated.

  • The clinical relevance is emphasized by our previous finding that the expression of GDF-9 is dysregulated in oocytes of women with Polycystic Ovary Syndrome [ 47 ] .

  • Tyrosine kinase activity is tightly regulated in normal cells, but is dysregulated due to mutation in some cancers, including lung cancer, resulting in enhanced proliferation and survival of cancer cells.

  • Although K562 cells are derived from leukemia, among the genes showing altered regulation were several that are also dysregulated in breast cancer, including c- myc and cyclin D2; their altered expression was verified by real-time PCR.


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