Words similar to dysregulated

Example sentences for: dysregulated

How can you use “dysregulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

Although K562 cells are derived from leukemia, among the genes showing altered regulation were several that are also dysregulated in breast cancer, including c- myc and cyclin D2; their altered expression was verified by real-time PCR.
Tyrosine kinase activity is tightly regulated in normal cells, but is dysregulated due to mutation in some cancers, including lung cancer, resulting in enhanced proliferation and survival of cancer cells.
The findings presented here, suggesting that different ECM signaling pathways are active in different cancers, could have important clinical implications, as knowledge of the specific pathways dysregulated in a particular cancer may be valuable for devising effective therapy that targets those pathways.
Moreover, normal cellular controls on cell-cycle progression appears to be dysregulated by HIV-1 expression because cell-cell contact and differentiation, events that normally lead to the down-regulation of cyclin D 1 expression [ 25 ] , did not significantly alter cyclin D 1 protein levels in HIV-1 infected podocytes.
The clinical relevance is emphasized by our previous finding that the expression of GDF-9 is dysregulated in oocytes of women with Polycystic Ovary Syndrome [ 47 ] .