Words similar to dysregulation
Example sentences for: dysregulation
How can you use “dysregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
As a consequence, osteoclast dysregulation leads to osteoporosis (decreased bone mass caused by excess osteoclast activity) or to osteopetrosis (increased bone mass caused by insufficient osteoclast activity).
However, one study [ 24 ] reported a potentially relevant correlation between symptoms of conduct disorder (but not depression) during adolescence and obesity in early adulthood, attributed to common mechanisms underlying "impulsive aggression" and dysregulation of body weight.
There was also an enrichment of genes associated with structure and permeability; in this class several genes were ubiquitously altered in both IBD and non-IBD samples, reflecting dysregulation of genes for paracellular permeability, degradation of extracellular matrix, and barrier protection against bacterial invasion of the epithelial surface.
Equally important, other studies have shown that loss-of-function and naturally occurring mutations in BMP ligands and receptors are associated with dysregulation of folliculogenesis and ovulation [ 14 15 16 17 18 19 ] . Of particular interest is the finding that ewes having a mutation in the bmp15 gene in both alleles are infertile whereas the heterozygotes are superfertile [ 16 ] . Thus, the bmp15 gene can control ovulation quota through a dosage-sensitive mechanism.
Immune dysregulation appears to play a key pathogenic role, as circulating autoantibodies are common in patients with certain JRA clinical subtypes [ 1 2 3 4 5 6 7 ] . Two recent studies have shown a highly significant association between early-onset pauciarticular JRA and circulating antibodies to the 43-kDa nuclear protein DEK [ 8 9 ] . Although circulating DEK antibodies have subsequently been found in children and adults with other autoimmune diseases [ 10 11 ] , these two studies did reveal that children with JRA are significantly more likely to have anti-DEK antibodies than are children without rheumatic disease.
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