Words similar to dysregulation
Example sentences for: dysregulation
How can you use “dysregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
As a consequence, osteoclast dysregulation leads to osteoporosis (decreased bone mass caused by excess osteoclast activity) or to osteopetrosis (increased bone mass caused by insufficient osteoclast activity).
There was also an enrichment of genes associated with structure and permeability; in this class several genes were ubiquitously altered in both IBD and non-IBD samples, reflecting dysregulation of genes for paracellular permeability, degradation of extracellular matrix, and barrier protection against bacterial invasion of the epithelial surface.
Equally important, other studies have shown that loss-of-function and naturally occurring mutations in BMP ligands and receptors are associated with dysregulation of folliculogenesis and ovulation [ 14 15 16 17 18 19 ] . Of particular interest is the finding that ewes having a mutation in the bmp15 gene in both alleles are infertile whereas the heterozygotes are superfertile [ 16 ] . Thus, the bmp15 gene can control ovulation quota through a dosage-sensitive mechanism.
It has been suggested that a dysregulation of MAP kinases is responsible for the growth factor deprivation [ 15 ] or chemotherapeutic agent [ 16 ] induced PCD.
Here, we ask whether infected podocytes expressing HIV-1 genes show the hallmarks of cyclin D 1 -dependent proliferation, specifically the up-regulation of cyclin D 1 transcript and protein expression and the subsequent phosphorylation of pRb on serine 780, a target site of active cyclin D 1 /CDK-4/6 that is not shared with cyclin E/CDK-2 complexes [ 24 ] . Utilizing two well-characterized models of HIVAN pathogenesis, HIV-1 transgenic mice [ 11 12 13 ] and HIV-1 infection of cultured podocytes [ 6 7 8 ] we find not only these hallmarks of cyclin D 1 -dependent proliferation, but also dysregulation of cyclin D 1 expression that normally occurs with cell-cell contact and differentiation [ 25 ] .
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