Words similar to dysregulation
Example sentences for: dysregulation
How can you use “dysregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Here, we ask whether infected podocytes expressing HIV-1 genes show the hallmarks of cyclin D 1 -dependent proliferation, specifically the up-regulation of cyclin D 1 transcript and protein expression and the subsequent phosphorylation of pRb on serine 780, a target site of active cyclin D 1 /CDK-4/6 that is not shared with cyclin E/CDK-2 complexes [ 24 ] . Utilizing two well-characterized models of HIVAN pathogenesis, HIV-1 transgenic mice [ 11 12 13 ] and HIV-1 infection of cultured podocytes [ 6 7 8 ] we find not only these hallmarks of cyclin D 1 -dependent proliferation, but also dysregulation of cyclin D 1 expression that normally occurs with cell-cell contact and differentiation [ 25 ] .
As a consequence, osteoclast dysregulation leads to osteoporosis (decreased bone mass caused by excess osteoclast activity) or to osteopetrosis (increased bone mass caused by insufficient osteoclast activity).
The second set of observations indicate that reactive oxygen species (ROS) activate PLD2 in a PKC-dependent manner [ 9 ] . There is much evidence that ROS generation is upregulated in AD brain [ 42 ] . Thus, it is possible that PLD2 may be activated in this disease resulting, perhaps, in dysregulation of PC metabolism.
Equally important, other studies have shown that loss-of-function and naturally occurring mutations in BMP ligands and receptors are associated with dysregulation of folliculogenesis and ovulation [ 14 15 16 17 18 19 ] . Of particular interest is the finding that ewes having a mutation in the bmp15 gene in both alleles are infertile whereas the heterozygotes are superfertile [ 16 ] . Thus, the bmp15 gene can control ovulation quota through a dosage-sensitive mechanism.
However, one study [ 24 ] reported a potentially relevant correlation between symptoms of conduct disorder (but not depression) during adolescence and obesity in early adulthood, attributed to common mechanisms underlying "impulsive aggression" and dysregulation of body weight.
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