Words similar to dysplastic
Example sentences for: dysplastic
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However, in both intervention and regression trials, significant CD4 +T cell and CD8 +T cell infiltration into hyperplastic/dysplastic islets and tumors was noted in Rip1-Tag2 mice that had received the combination of sub-lethal radiation and adoptive transfer of TCR splenocytes.
Small foci of dysplastic precancers (Class 1) may arise from the diffuse hyperplasias and metaplasias.
The mice show systemic tolerance to Tag, mounting neither humoral nor cellular immune responses to Tag upon immunization of purified protein [ 25 26 ] . Rip1-Tag2 mice display a reproducible pattern of multistage tumor development, from normal islets to hyperplastic/dysplastic islets, to angiogenic islets, to varying grades of solid tumor, with a well-defined angiogenic progression [ 27 ] . All Rip1-Tag2 mice succumb to hypoglycemia and tumor burden by 13-16 weeks.
2 arrest, as well as apoptosis via p53-dependent and p53-independent pathways [ 50 51 52 ] . The presence of a dysplastic SMG phenotype in E2f1 -/-mice indicates that E2F1 plays an important role during SMG development [ 53 ] . Moreover, E2F1 overexpression in human salivary gland (HSG) cells diverted these cells into an apoptotic pathway [ 54 ] .
Frequent allelic loss at chromosomal locations 2q, 3p, 4q, 6p, 6q, 8p, 8q, 9p, 11q, 13q, 14q and 17q is observed in head and neck cancer [ 4 8 9 10 11 ] . Molecular studies of hyperplastic, dysplastic, CIS, and invasive head and neck lesions indicate that loss of heterozygosity at chromosomal locations 3p, 9p and 17p are early events in head and neck carcinogenesis [ 4 12 ] . Specific tumor suppressor genes, such as FHIT (3p14.