Words similar to dysfunction
Example sentences for: dysfunction
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Improvements in the management of patients with thalassemia major in the past four decades have resulted in "one of the most dramatic alterations in morbidity and mortality associated with a genetic disease" [ 2 ] . Regular red blood cell transfusions extend survival, eliminate complications of anemia, inhibit bone marrow hyperactivity, and support normal growth and development in patients with thalassemia major [ 3 ] . Unfortunately, regular transfusions also lead to the accumulation of tissue iron, loading the body's organs to the point of dysfunction and finally death in the second or third decade of life if left untreated [ 4 ] .
Maintenance of splanchnic blood flow is important because splanchnic hypoperfusion may play a critical role in the pathogenesis of multiorgan dysfunction syndrome [ 2 3 ] . Mechanical ventilation has been suggested to potentiate the adverse effects of underlying critical illness on splanchnic vasculature and contribute to the development of multiorgan dysfunction syndrome, particularly when 'injurious' ventilatory strategies that produce high end-inspiratory lung volumes are employed [ 3 ] . Experimental studies suggested that mechanical ventilation with considerably high levels of PEEP can lead to splanchnic hypoperfusion and marked reduction in hepatic blood flow [ 4 5 6 ] . Furthermore, PEEP may decrease splanchnic blood flow in patients with no underlying lung disease [ 7 8 ] . Most available evidence regarding the effects of PEEP from animal studies has been extrapolated to humans based on the assumption that the effects of mechanical ventilation on humans and animals are similar.
Brain dysfunction is poorly understood.
Free-radicals ( e.g. , superoxide, hydroxyl radicals, nitric oxide and peroxynitrite) have long been thought to be a key element in the cellular dysfunction and death that are central to the pathogenesis of many aspects of diabetes.
[ 13 ] have reported that respiration dysfunction and hypoxemia were improved and pulmonary hypertension decreased in pigs that were administered ibuprofen after Pseudomonas aeruginosa infusion.
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