Words similar to duplicon
Example sentences for: duplicon
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On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.
However, there is highly significant homology over ~100-kb of sequence from assembly contig NT_035325 mapping to 15q26, where LCR-15 duplicon sequences have been reported [ 18 ] . These sequences appear to correspond to the LCR15 class of duplicons, based on sequence content.
This class of duplicon has been proposed to help mediate rearrangements in idic(15) markers and larger interstitial duplications and triplications [ 19 ] .
3 previously described by Riley et al . [ 17 ] , and several copies of a duplicon described as Golgin-linked-to-PML (GLP) [ 18 ] and as LCR15 [ 19 20 21 ] . A third, previously undetected, potential segmental duplication was identified in the proximal third of the 600 kb region (Figure 4, indicated by the asterisk).
The second duplicon recognized within the 600 kb sub-interval was originally described as the Golgin-Linked-to-PML (promyelocytic leukemia) duplicon, or GLP duplicon, by Gilles et al . [ 18 ] and subsequently described as LCR15 by Pujana et al . [ 19 ] , Gratacos et al . [ 20 ] and Pujana et al.
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