Words similar to duplicon
Example sentences for: duplicon
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On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.
With our results indicating the CHRNA7 sequence is single copy in the chimpanzee genome and thus unlikely to be involved in the inversion, the GLP/LCR15 duplicon is therefore the best candidate sequence for being present at the site of the pericentric inversion.
This sequence, while short, does not correspond to any of the known chromosome 15q11-q13 duplicon sequences, and therefore could represent a novel class of such low copy repeats.
Although the CHRNA7 duplication had, on the basis of sequence identity, previously been postulated to be human-specific, the location of this duplicon within the 600 kb interval associated with the pericentric inversion in chimpanzee necessitated determination of the copy number of CHRNA7 within the chimpanzee genome [ 17 ] . First, chimpanzee BAC library hybridizations (8.
Interestingly, the extent of the segmental duplications in the 1 Mb region examined was restricted to the clones that showed the dual FISH signal in PTR XVp and XVq and each clone that produced dual FISH signals contained a GLP/LCR15 duplicon by sequence analysis (Figure 4).
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