Words similar to dr-
Example sentences for: dr-
How can you use “dr-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Initial studies were based on a well characterized binding site for CAR/RXR heterodimers, the DR-5 element from the promoter of the retinoic acid receptor β2 isoform [ 8 9 16 ] . In agreement with the biochemical results, the rexinoid blocked both the stimulatory effect of the agonist and the inhibitory effect of the inverse agonist on this element (Fig.
These results show that the negative effects of rexinoids on TCPOBOP and androstanol signaling observed with the DR-5 site from the RARβ promoter are not observed with the DR-4 and ER-6 sites from the CYP promoters.
HNFs may compete with PPARs for binding to DR-1 elements.
PPREs are direct repeats (DR) of a hexanucleotide sequence AGGTCA separated by one nucleotide and are therefore referred to as a DR-1 response element [ 30 ] . PPARα and PPARγ play critical roles in the catabolism and storage of FA, whereas the function of PPARδ is less certain.
The βRARE-TK-Luc reporter plasmid with three copies of the DR-5 motif from the promoter of the mouse RARβ2 gene has been described previously, as has the CYP2B10-TK-Luc reporter with two copies of the DR-4 type elements from the promoter of the mouse CYP2B10 gene and the CYP3A4-TK-luc reporter with three copies of the ER-6 element from the human CYP3A4 promoter [ 16 ] . Expression vectors for full length mCAR and RXR proteins were as described [ 9 ] . The cdm8-mCARΔ8 deletion construct containing a deletion of the last 8 amino acids and the mutant with 2 helix 3 mutations (F171L, I174A) that block ligand binding and response have been described previously [ 16 ] , as has the cdm8-RXRΔ19 construct with a deletion of the last 19 amino acids [ 3 ] .
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