Example sentences for: dqa

How can you use “dqa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In this study, we examine the characteristics of DEK binding to the Y-box sequences of DQA1*0101, DQA1*0501, DRA, DQB , and DRB . We also confirm participation of DEK with NF-Y in the DQA1 Y-box binding complex and localize specific DEK binding within this sequence.

  • The DQA1*0501 promoter region (QAP 4.1), in which a single-base-pair polymorphism in the Y box significantly diminishes transcriptional activity [ 33 ] , is a component of the so-called susceptibility haplotype for autoimmune disease.

  • Finally, DEK binds differentially to specific Y-box sequences found in HLA-DQA1(*0101 and *0501 alleles) and HLA-DRA , consistent with observations of DQA1 gene-specific cell-surface expression [ 36 ] and allele-specific promoter activity [ 33 ] . The specificity of rDEK binding to these and other, related Y-box sequences (including HLA-DQB and HLA-DRB alleles associated with the DR4 haplotype) may correlate with a predisposition to autoim-mune disease seen with certain HLA haplotypes.

  • The 148-bp probe included DQA1*0101 promoter sequence from -53 to -200.

  • Further characterization of rDEK binding to the polymorphic DQA1*0501 Y-box sequence and to the consensus ( HLA-DRA ) Y-box sequence establishes a relative hierarchy of DEK binding activity (Fig.


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