Words similar to docking
Example sentences for: docking
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In order to optimize the conformation of this pocket, all residues within 7A of the HEPES molecule that were not identical between template and model were energy-minimized in the internal coordinate space [ 8 ] . The resulting models were used for docking experiments.
Rab proteins comprise a large family of Ras-related GTPases that function in the anterograde and retrograde trafficking of proteins in mammalian cells [ 1 2 3 ] . Different Rab proteins reside in specific subcellular membranes or organelles, where they mediate vesicular transport between discrete donor and acceptor compartments in the endocytic or exocytic pathways [ 4 5 ] . Detailed studies of a few Rab proteins ( e.g .; Rab1, Rab5 and Rab9) have led to a general model wherein Rab proteins are presumed to cycle on and off donor and acceptor membranes in connection with changes in their guanine nucleotide state [ 6 7 8 ] . In the active GTP-bound state, Rab proteins associate with budding transport vesicles [ 9 10 11 ] and appear to participate in the assembly of membrane docking complexes [ 12 13 14 ] . Following vesicle fusion with the acceptor compartment and GTP hydrolysis, the inactive GDP-bound Rab is extracted from the membrane by a carrier protein termed guanine nucleotide dissociation inhibitor (GDI) [ 15 16 17 ] . The GTPase can then re-enter the transport cycle through nucleotide exchange promoted by a specific exchange factor at the donor vesicle membrane [ 18 19 20 ] . In addition to changes in guanine nucleotide state, the posttranslational prenylation of Rab proteins plays an important role in the cycling mechanism.
The entire gp120 surface was considered for docking acetylated and phthaloylated cellotetraose (CTAP) except the trimerization and CD4 binding sites on gp120 [ 13 ] . The two optimally docked CTAP molecules were selected for further analyses.
In response to receptor activation, Syk becomes non-covalently associated with the BCR through tandem SH2 domains located in the amino terminal half of the protein [ 44 ] . Following engagement of the BCR, phosphorylation of specific tyrosine residues in immunoreceptor tyrosine-based activation motifs (ITAMs) found within the cytoplasmic tails of CD79a and CD79b provides docking sites for Syk localization [ 45 46 47 ] . The ability of phosphorylated ITAM peptides to selectively enhance Syk kinase activity in vitro suggests that recruitment of Syk to the receptor complex may serve to activate the kinase, in part, through allosteric changes in the structure of the Syk protein [ 44 48 49 ] . Upon activation, Syk and the receptor complex become localized in detergent-resistant cholesterol-rich membrane microdomains (lipid rafts), resulting in the segregation of the BCR complex from other membrane components [ 50 ] .
All these correlations represent a significant improvement over the protein-rigid docking results.
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