Example sentences for: dna-pk

How can you use “dna-pk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The GSK3β phosphorylation site was identified by mutagenesis as serine 33 of p53, and we were able to show that this was dependent on prior phosphorylation of serine 37 by DNA-PK.

  • A key question is whether DNA-PK or some other kinase phosphorylates serine 37 of p53 in vivo.

  • However, prephosphorylation of p53-GST by DNA-PK resulted in strong phosphorylation of p53 by GSK3β (fig 1) but not GSK3α.

  • p53-GST was then prephosphorylated with MAP kinase, S6 kinase, Protein Kinase A, DNA-PK and Protein Kinase C (fig 1) or Casein Kinase II and JNK1/JNK2 (data not shown).

  • A more likely candidate is the Atr protein kinase, a kinase related to DNA-PK [ 44], which can regulate the phosphorylation of serine 37 of p53 in response to DNA damage.


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