Example sentences for: dna-damage

How can you use “dna-damage” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Bailey, personal communication; M. Brodsky, personal communication; [ 16]; E. De Gregorio personal communication; A. Tang, personal communication; and P. Tomancak, personal communication), which study five different experimental questions - aging, DNA-damage response, immune response, resistance to DDT, and embryonic development.

  • In type 1 diabetes, it has been shown that inflammatory cytokines play a central role in the destruction of insulin producing β-cells [ 17 18 19 ] , resulting in the production of oxygen-derived free radicals that induce DNA-damage and apoptosis in both rodent and human β-cells [ 20 21 22 23 24 25 ] . In both type 1 and type 1, as well as, type 2 diabetes, the role of free radicals in diabetic complications is well studied.

  • Cisplatin causes two types of DNA damage, DNA adducts and inter-stranded cross-linking, resulting in activation of apoptosis pathway in the target tumor cells [ 13 14 ] . Our results suggest that inhibition of tyrosine kinase activity of the potential targets by Gleevec appear to potentiate the effect of cisplatin in DNA-damage induced apoptosis in A549 cells.

  • GSK3β-dependent phosphorylation of p53 at serine 33 may be part of other p53-regulatory pathways, such as oncogene activation or apoptosis, which are not directly activated by DNA-damage.

  • Moreover, it is possible that β-cells from patients with longstanding diabetes have a higher threshold for an apoptotic response to DNA-damage than β-cells in normal subjects, as it has been shown that this threshold increases with age [ 43 ] . Consequently, β-cells with high levels of DNA damage from younger individuals with a shorter duration of diabetes might be eliminated by apoptosis, while similarly damaged β-cells from older individuals, who are likely to have had diabetes for a longer time may be resistant to apoptosis and so remain.


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