Example sentences for: dna-binding

How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We show here that KilA-N and Bro-N domains are two DNA-binding domains that are widespread in large DNA viruses infecting bacteria and eukaryotes.

  • Additionally, two AT-hook like modules, which probably had an accessory DNA-binding function, were also inserted into a conserved α-helix directly N-terminal of the DPBB domain in the β' subunit.

  • This region can, by itself, activate transcription when targeted to the DNA via a heterologous DNA-binding domain [ 5 ] . On the other hand, the LRR plus C-terminal region of yCCR4 cannot mediate transcription activation, but is involved in protein-protein interactions [ 5 ] . The yCCR4 LRR is necessary for the binding of several components of the CCR4-NOT complex, including yPOP2 -and mCAF1- [ 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] , and deletion of the yCCR4 N-terminus does not impair these associations.

  • Previously, AT-hooks have been detected primarily in eukaryotic chromatin-associated proteins, particularly transcription factors, where they function as accessory DNA-binding domains [ 74 ] . The ubiquity of the AT-hook-like modules in the β' subunits of DDRPs suggests that they were recruited for nucleic acid recognition in LUCA if not earlier.

  • The phosphorylation of Smad1 at the carboxylterminal SSVS motif triggers the release of Smad1 from the receptor, the formation of homo-oligomers of Smad1 and hetero-oligomers of Smad1 and Smad4, and the subsequent nuclear translocation of both Smad1 and Smad4 [ 6 9 10 ] . In the nucleus, Smad1 and Smad4 function as DNA-binding transcriptional regulators [ 9 ] . However, there is a unique feature in Smad-regulated transcription.


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