Words similar to dna-binding
Example sentences for: dna-binding
How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
DEK is a nuclear protein that is not structurally related to any known family of proteins [ 12 13 ] . Although it may also participate in DNA replication and RNA processing [ 14 15 ] , we have identified DEK as a DNA-binding protein that recognizes the TG-rich peri- ets (pets) regulatory element in the human immunodeficiency virus type 2 (HIV-2) enhancer [ 16 ] . The pets site is important in mediating HIV-2 enhancer stimulation in activated T cells and monocytes [ 17 18 19 ] , suggesting that DEK may play an immunomodulatory role as it participates in transcriptional activation through this and related sites.
The phosphorylation of Smad1 at the carboxylterminal SSVS motif triggers the release of Smad1 from the receptor, the formation of homo-oligomers of Smad1 and hetero-oligomers of Smad1 and Smad4, and the subsequent nuclear translocation of both Smad1 and Smad4 [ 6 9 10 ] . In the nucleus, Smad1 and Smad4 function as DNA-binding transcriptional regulators [ 9 ] . However, there is a unique feature in Smad-regulated transcription.
Previously, AT-hooks have been detected primarily in eukaryotic chromatin-associated proteins, particularly transcription factors, where they function as accessory DNA-binding domains [ 74 ] . The ubiquity of the AT-hook-like modules in the β' subunits of DDRPs suggests that they were recruited for nucleic acid recognition in LUCA if not earlier.
Currently, Smad1 is regarded as a DNA-binding transcriptional modulator that is activated by the BMP type I receptors.
Sequence comparison of NFAT proteins revealed that the DNA-binding domain and a region referred to as the NFAT homology region (NHR) share sequence similarity, while other regions of the NFAT proteins share little or no sequence similarity (a schematic of NFATp is shown in Figure 1A) [ 1].
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