Words similar to dna-binding
Example sentences for: dna-binding
How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
We show here that KilA-N and Bro-N domains are two DNA-binding domains that are widespread in large DNA viruses infecting bacteria and eukaryotes.
Additionally, two AT-hook like modules, which probably had an accessory DNA-binding function, were also inserted into a conserved α-helix directly N-terminal of the DPBB domain in the β' subunit.
This region can, by itself, activate transcription when targeted to the DNA via a heterologous DNA-binding domain [ 5 ] . On the other hand, the LRR plus C-terminal region of yCCR4 cannot mediate transcription activation, but is involved in protein-protein interactions [ 5 ] . The yCCR4 LRR is necessary for the binding of several components of the CCR4-NOT complex, including yPOP2 -and mCAF1- [ 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] , and deletion of the yCCR4 N-terminus does not impair these associations.
Previously, AT-hooks have been detected primarily in eukaryotic chromatin-associated proteins, particularly transcription factors, where they function as accessory DNA-binding domains [ 74 ] . The ubiquity of the AT-hook-like modules in the β' subunits of DDRPs suggests that they were recruited for nucleic acid recognition in LUCA if not earlier.
The phosphorylation of Smad1 at the carboxylterminal SSVS motif triggers the release of Smad1 from the receptor, the formation of homo-oligomers of Smad1 and hetero-oligomers of Smad1 and Smad4, and the subsequent nuclear translocation of both Smad1 and Smad4 [ 6 9 10 ] . In the nucleus, Smad1 and Smad4 function as DNA-binding transcriptional regulators [ 9 ] . However, there is a unique feature in Smad-regulated transcription.
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