Words similar to dna-binding
Example sentences for: dna-binding
How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
All members of the HMG-box family possess a 70-80 amino acid DNA-binding domain (the HMG-box) related to a motif originally identified in HMGB1 [ 5 ] . The HMG-box may also be involved in protein-protein interactions.
Thus, the Bro-N domain appears to define a distinct superfamily of widespread viral DNA-binding domains.
This technique, first established by Andrew Belmont and collaborators [ 14], entails the construction of a fusion protein between GFP and the DNA-binding domain (DBD) of a known heterologous transcription factor.
C/EBP is previously reported to be an important accessory factor for transactivation by several other transcription factors [ 26 ] . C/EBPβ was shown to transactivate the α1-acid glycoprotein gene promoter even when mutated in the DNA-binding domain, and this activation appeared to depend on protein-protein interaction with glucocorticoid receptor through the leucine zipper region [ 27 ] . Recently, a conserved domain in C/EBPα and C/EBPβ was shown to mediate cAMP responsiveness, strengthening the fact that C/EBP may be characterized as a cAMP-responsive nuclear regulator [ 28 29 ] . On the COX-2 promoter in granulosa cells, cAMP-mediated regulation was shown to be mediated primarily by an E-box that bind USF1 and USF2 isoforms in a manner resembling the RIIβ E-box in Sertoli cells [ 30 ] . Transactivation of the COX-2 gene in skin carcinoma cells is highly dependent on this E-box together with a C/EBP binding site that bind C/EBPβ and C/EBPδ [ 31 ] . These data strengthens a model of formation of a cAMP-responsive unit (CRU) containing USF and C/EBP.
Experimental studies on the TCRs of MET3 and MET28 have demonstrated that the binding of Cbf1p enhances the DNA-binding affinity of Met31/32p [ 5 ] . Indeed, biochemical experiments suggest that all these proteins may interact at the TCRs of some sulfur-utilization genes [ 5 ] .
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