Words similar to dna-binding
Example sentences for: dna-binding
How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
The transcriptional regulatory activities of Smad1 in the nucleus are associated with its ability to directly bind to DNA [ 12 ] , its interaction with other DNA-binding transcription factors, such as OAZ, SIP1 and Hoxc-8 [ 13 14 15 ] , and also its interaction with the master transcriptional co-activator CBP/p300 [ 16 ] . Smad4 is an essential functional partner in Smad-regulated transcription and also interacts with CBP/p300 via a domain within the central linker region named as SAD (Smad Activation Domain) [ 13 ] . Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
An 11-amino-acid-long acidic domain from the RelA subunit of NFκ-B is capable of minimal activating behavior when fused to the Gal4 DNA-binding domain (Gal4BD) [ 23 ] . The sequence, when joined together in tandem arrays, is as potent as the wild type RelA transactivator.
The double-stranded DNA-binding activity in E. coli topoisomerase III required for highly efficient decatenation activity is attributed to a 17-amino-acid residue with no counterpart in E. coli topoisomerase I [ 28 29 ] . It may be required for interaction with the passing double-strand of DNA in the decatenation mechanism.
We show here that KilA-N and Bro-N domains are two DNA-binding domains that are widespread in large DNA viruses infecting bacteria and eukaryotes.
Statistical significance was measured by drawing pathways from membrane proteins to DNA-binding proteins through the experimentally determined protein-interaction map (henceforth called "real pathways") and comparing these pathways with pathways drawn through control interaction maps that were created by randomizing all pairwise interactions in the original dataset.
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