Words similar to dna-binding
Example sentences for: dna-binding
How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
In biochemical experiments the DNA-binding domains of NFAT proteins (with the exception of NFAT5) are sufficient for cooperative DNA-binding in association with Fos/Jun heterodimers [ 4, 10, 11].
Smads have been shown to mediate transcription via modulating the transcriptional activity of many other DNA-binding proteins.
The C-terminal region of DEK, which contains the putative DNA-binding domain, appears to be most antigenic [ 34 ] (and K Sitwala and DM Markovitz, unpublished observations), raising the possibility that altered DNA binding may expose other masked epitopes.
The yeast two-hybrid system exploits this modular feature of transcriptional activators [ 12 13 ] . Several variants of this general approach have been devised that employ DNA-binding domain and activation domain fusion proteins to assess and/or recover proteins that interact.
The transcriptional regulatory activities of Smad1 in the nucleus are associated with its ability to directly bind to DNA [ 12 ] , its interaction with other DNA-binding transcription factors, such as OAZ, SIP1 and Hoxc-8 [ 13 14 15 ] , and also its interaction with the master transcriptional co-activator CBP/p300 [ 16 ] . Smad4 is an essential functional partner in Smad-regulated transcription and also interacts with CBP/p300 via a domain within the central linker region named as SAD (Smad Activation Domain) [ 13 ] . Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
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