Words similar to dna-binding
Example sentences for: dna-binding
How can you use “dna-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
The phosphorylation of Smad1 at the carboxylterminal SSVS motif triggers the release of Smad1 from the receptor, the formation of homo-oligomers of Smad1 and hetero-oligomers of Smad1 and Smad4, and the subsequent nuclear translocation of both Smad1 and Smad4 [ 6 9 10 ] . In the nucleus, Smad1 and Smad4 function as DNA-binding transcriptional regulators [ 9 ] . However, there is a unique feature in Smad-regulated transcription.
TFs are usually classified according to the presence of conserved DNA-binding domains [ 2 ] . The DNA-binding domain is responsible for recruiting TFs to specific cis -regulatory DNA sequences in the promoters of the genes they regulate.
The BTB domain is a highly conserved 120 amino acid, hydrophobic-rich, protein-protein interaction domain that mediates homodimerization and heterodimerization of a large number of proteins with diverse functions [ 9 ] . The three dimensional structure of one BTB domain [ 33 ] has been characterized through structure-function studies [ 34 ] . Proteins containing BTB domains are currently categorized into three groups [ 35 ] : 1) DNA-binding proteins often containing zinc fingers in the C-terminal region, 2) actin binding proteins that contain a kelch repeat of ~50 residues that terminate in a pair of glycine residues [ 36 ] and 3) proteins that have neither an actin-binding domain nor a DNA-binding domain.
This technique, first established by Andrew Belmont and collaborators [ 14], entails the construction of a fusion protein between GFP and the DNA-binding domain (DBD) of a known heterologous transcription factor.
Our program, NetSearch, draws all possible linear paths of a specified length through the interaction map starting at any membrane protein and ending on any DNA-binding protein.
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