Words similar to disulfide
Example sentences for: disulfide
How can you use “disulfide” in a sentence? Here are some example sentences to help you improve your vocabulary:
contains three glutaredoxins that utilize the reducing power of glutathione to catalyze the reduction of disulfide bonds (–S–S–) in the presence of NADPH and glutathione reductase.
A structure model of ButaIT, generated from the Swiss-model protein modeling server based on the structural coordinates of chlorotoxin [ 38 ] and insectotoxin I5A [ 22 ] showed that ButaIT adopts a typical core structure of scorpion toxins primarily composed of one α-helix and three β-strands with four disulfide bridges, a feature similar to other toxins of similar size that act on K +and Cl -channels [ 17 31 34 38 ] . It is also evident from the data that disulfide bridge formation in ButaIT likely follows a common motif, with covalent links between cysl6-cys32, cys5-cys27, cys20-cys34 and an additional disulfide bridge between cys2 and cys 19 which cross-links the N-terminal strand of the β-sheet to the α-helix.
As mentioned above, proteins—in particular, the thiols of cysteines—are the major targets of H 2 O 2 . The reaction of cysteinyl thiolates with H 2 O 2 can lead to the formation of different modifications, such as sulfenic acid (–SOH), sulfinic acid (–SO 2 H), and sulfonic acid (–SO3H), as well as disulfide bond formation (–S–S–) and glutathione conjugation (–S–GSH) (Jacob et al.
4) which is in agreement with the molecular mass calculated from the amino acid sequence when the toxin is in its native form with four disulfide bridges as observed in other similar toxins.
Presumably, reduction of the disulfide restores the binding of zinc and its inhibitory association with the sigma factor.
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