Example sentences for: disulfide-linked

How can you use “disulfide-linked” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The α 2 -δ subunit is a highly glycosylated ∼ 175 kDa protein formed by two disulfide-linked peptides encoded by the same gene.

  • The CD98 (4F2, FRP-1) molecule, a cell surface disulfide-linked heterodimer, was originally described as a T cell activation antigen [ 1 ] , and later was shown to provide a co-stimulatory signal for CD3-mediated T-cell activation [ 2 ] , independent of CD28/CD80/CD86 interaction [ 3 ] . In other studies, triggering of human monocyte CD98 could suppress T cell proliferation [ 4 ] , or promote homotypic cell aggregation of monocytes [ 5 ] . Also, CD98 may be a target antigen for natural killer cells [ 6 ] , may mediate fusion of blood monocytes leading to osteoclast formation [ 7 8 ] , and may modulate hematopoietic cell survival and differentiation [ 9 ] .

  • Of these, one recognized CD63 as reported previously [ 30 ] , and three (including mAb 6B12) recognized a disulfide-linked cell surface heterodimer consisting of an 85 kD heavy chain and a 35 kD light chain.

  • The dihydropyridine receptor (DHPR) of skeletal muscle consists of α 1S , α 2 , β 1a and γ 1 subunits [ 1 ] . The α 1 subunit is a large four-repeat transmembrane protein of ~220 KDa that contains the basic functional elements of the L-type Ca 2+channel, including the Ca 2+selective pore and S4 "voltage-sensing" transmembrane segments in each of the four internal repeats [ 2 ] . β subunits are ~65 kDa cytosolic proteins essential for membrane trafficking, modulation of channel kinetics, and for excitation-contraction (EC) coupling [ 3 4 ] . The α 2 subunit is a highly glycosylated ~175 kDa protein formed by two disulfide-linked peptides [ 5 ] , whereas the γ 1 subunit is a ~32 kDa skeletal muscle-specific protein of four presumptive transmembrane domains with almost unknown function [ 6 7 ] .

  • Because the proteins recognized by 6B12 resembled the disulfide-linked 85 and 35 kD subunits of CD98 [ 38 39 ] , they were compared to authentic CD98 as precipitated using mAb 4F2.


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