Example sentences for: disease-causative

How can you use “disease-causative” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Patient 07 has a C->T substitution in exon 23 at bp 3359 predicting a nonsense mutation Arg->Stop, leading to a likely disease-causative truncation of the protein.

  • Two of the patients in which we found disease-causative mutations have affected brothers, three in addition to patient 01, have potential carrier sisters, and all six have mothers who could also be carriers.

  • Patient 01 and his carrier sister were shown to have a C->T substitution in exon 39 bp5762, predicting a nonsense mutation Gln->Stop, leading to a likely disease-causative truncation of the protein (Table 2and Figure 1).

  • Details of the reagent costs per patient calculations are attached as Additional file A. Briefly, we assumed that likely disease-causative mutations would be found, on average, within approximately 43 fragments.

  • As we found no likely disease-causative mutations in our first pass DHPLC conditions, we sequenced all four patients exons 56-78 and the 7 fragments of the 3'-UTR (the first of which contains exon 79).


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