Example sentences for: disease-associated

How can you use “disease-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A naturally occuring Asn57Asp polymorphism may be associated with JOAG [ 39 ] which, if truly disease-associated, would suggest the functional importance of N-linked glycosylation.

  • These multiple alignments have then been used to assess the difference in evolutionary conservation for positions that are both disease-associated and not associated.

  • Reported mutations often occur in the highly conserved alpha-helix-initiation motif of rod domain 1A or in the alpha-helix-termination motif of rod domain 2B [ 19 ] . Structure based analysis methods have also been used to analyze Osteogenesis imperfecta associated COL1A1 mutations and disease-associated P53 mutations (Mooney and Klein, unpublished), [ 20 ] . Miller and Kumar have reported that disease-associated mutations are conserved in seven model genes [ 21 ] .

  • An analysis of the breast and ovarian cancer susceptibility gene, BRCA1, showed that disease-associated mutations tend to occur in highly conserved regions [ 18 ] . An analysis of homologous sequences in the androgen receptor has shown similar results [ 10 ] . Keratin 12, KRT12, is associated with Meesmann Corneal Epithelial Dystrophy (MCD).

  • While it has been shown in specific cases that disease-associated amino acid substitutions affect protein function, until now few studies have examined this across many genes.


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