Words similar to disease-associated
Example sentences for: disease-associated
How can you use “disease-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:
A naturally occuring Asn57Asp polymorphism may be associated with JOAG [ 39 ] which, if truly disease-associated, would suggest the functional importance of N-linked glycosylation.
While it has been shown in specific cases that disease-associated amino acid substitutions affect protein function, until now few studies have examined this across many genes.
The finding that disease-associated mutations occur in positions of functional importance supports recent efforts for the building of methods to predict which positions are likely to be disease associated [ 14 13 16 17 ] . These methods are likely to incorporate protein structure, the amino acid identity of the mutation and phylogenetic information.
Reported mutations often occur in the highly conserved alpha-helix-initiation motif of rod domain 1A or in the alpha-helix-termination motif of rod domain 2B [ 19 ] . Structure based analysis methods have also been used to analyze Osteogenesis imperfecta associated COL1A1 mutations and disease-associated P53 mutations (Mooney and Klein, unpublished), [ 20 ] . Miller and Kumar have reported that disease-associated mutations are conserved in seven model genes [ 21 ] .
The relationship between disease-associated mutation positions and evolutionary conservation has been reported in specific cases.