Example sentences for: disease-associated

How can you use “disease-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While it has been shown in specific cases that disease-associated amino acid substitutions affect protein function, until now few studies have examined this across many genes.

  • Here we provide direct evidence that disease-associated point mutations occur in functionally important regions of the genome and are not distributed equally across the coding regions of genes.

  • To determine the degree to which mutation positions differ evolutionarily from other positions, we have built alignments of homologous genes for 231 disease-associated genes.

  • Reported mutations often occur in the highly conserved alpha-helix-initiation motif of rod domain 1A or in the alpha-helix-termination motif of rod domain 2B [ 19 ] . Structure based analysis methods have also been used to analyze Osteogenesis imperfecta associated COL1A1 mutations and disease-associated P53 mutations (Mooney and Klein, unpublished), [ 20 ] . Miller and Kumar have reported that disease-associated mutations are conserved in seven model genes [ 21 ] .

  • The goal of this work is to build these alignments, map the mutations to them, and show that disease-associated positions are, in general, conserved.


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