Example sentences for: disease-associated

How can you use “disease-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A naturally occuring Asn57Asp polymorphism may be associated with JOAG [ 39 ] which, if truly disease-associated, would suggest the functional importance of N-linked glycosylation.

  • While it has been shown in specific cases that disease-associated amino acid substitutions affect protein function, until now few studies have examined this across many genes.

  • The finding that disease-associated mutations occur in positions of functional importance supports recent efforts for the building of methods to predict which positions are likely to be disease associated [ 14 13 16 17 ] . These methods are likely to incorporate protein structure, the amino acid identity of the mutation and phylogenetic information.

  • Reported mutations often occur in the highly conserved alpha-helix-initiation motif of rod domain 1A or in the alpha-helix-termination motif of rod domain 2B [ 19 ] . Structure based analysis methods have also been used to analyze Osteogenesis imperfecta associated COL1A1 mutations and disease-associated P53 mutations (Mooney and Klein, unpublished), [ 20 ] . Miller and Kumar have reported that disease-associated mutations are conserved in seven model genes [ 21 ] .

  • The relationship between disease-associated mutation positions and evolutionary conservation has been reported in specific cases.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast