Example sentences for: disease-associated

How can you use “disease-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The goal of this work is to build these alignments, map the mutations to them, and show that disease-associated positions are, in general, conserved.

  • While it has been shown in specific cases that disease-associated amino acid substitutions affect protein function, until now few studies have examined this across many genes.

  • Here we provide direct evidence that disease-associated point mutations occur in functionally important regions of the genome and are not distributed equally across the coding regions of genes.

  • An analysis of the breast and ovarian cancer susceptibility gene, BRCA1, showed that disease-associated mutations tend to occur in highly conserved regions [ 18 ] . An analysis of homologous sequences in the androgen receptor has shown similar results [ 10 ] . Keratin 12, KRT12, is associated with Meesmann Corneal Epithelial Dystrophy (MCD).

  • These multiple alignments have then been used to assess the difference in evolutionary conservation for positions that are both disease-associated and not associated.


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