Example sentences for: diphosphokinase

How can you use “diphosphokinase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Although mitochondria from lymphoblasts (above) and other mammalian cells [ 13 ] were found to take up thiamine, the physiological significance of the uptake is unknown given that thiamine diphosphokinase is cytosolic and mitochondria cannot convert thiamine to ThDP [ 14 16 21 ] . We thus were interested in uptake of ThDP by mitochondria, a possibility demonstrated previously with rat liver [ 14 ] . Mitochondria from normal human lymphoblasts were able to take up ThDP in a saturable, biphasic manner (fig.

  • Thiamine entry into mammalian cells occurs by a saturable, high affinity transporter that is deficient in humans with thiamine-responsive megaloblastic anemia (TRMA) [ 7 8 9 10 11 12 ] . Thiamine uptake by mitochondria has been demonstrated [ 13 ] , yet thiamine diphosphokinase is cytosolic and mitochondria cannot convert thiamine to ThDP [ 14 15 16 ] . Barile and coworkers demonstrated saturable uptake of ThDP by rat liver mitochondria characterized by a K m of around 20 μM.

  • Upon being taken up by a cell, thiamine is rapidly diphosphorylated by thiamine diphosphokinase to give thiamine diphosphate (ThDP) [ 3 ] . Thus, thiamine represents only a few percent of the total cellular thiamine/thiamine phosphate derivatives.


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