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Example sentences for: dids
How can you use “dids” in a sentence? Here are some example sentences to help you improve your vocabulary:
To test this hypothesis, the effects of 4-AP on membrane potential were examined using GC incubated in either media modified to contain the chloride channel antagonist DIDS, or a physiological buffer solution modified to contain a low (8 mM) concentration of chloride.
The observed effects of Cl -channel antagonists differ significantly between the present study where DIDS prevented 4-AP from decreasing progesterone synthesis and previous investigations where DIDS and other Cl -channel antagonists prevented LH from enhancing progesterone production [ 29 35 56 ] . However, this discrepancy is expected, because DIDS antagonizes a chloride influx pathway in pig GC, and chloride efflux pathways in Leydig cells.
Membrane potential was further depolarized in GC exposed to 4-AP in the presence of DIDS (Figure 8B), consistent with the hypothesis that 4-AP-induced hyperpolarization depends on chloride influx.
Interestingly, concomitant exposure to DIDS prevented 4-AP from diminishing the accumulation of progesterone in GC culture media (Figure 8C), suggesting that chloride influx, membrane hyperpolarization or both might mediate this effect of 4-AP.
Exposure to DIDS alone significantly decreased (depolarized) GC resting membrane potential (Figure 8B), suggesting that an outward chloride current (chloride influx) contributes to the normal resting potential of pig GC.