Example sentences for: dexfenfluramine

How can you use “dexfenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Initial reports of remarkably high prevalence of aortic and mitral regurgitation (AR and MR) as assessed by echocardiography in five separate populations [ 2 ] were subsequently supported by most [ 3 4 5 ] but not all investigators [ 6 ] . These uncontrolled reports were soon followed by a series of studies in which prevalence of echocardiographically-defined AR and MR were assessed in persons who had taken fenfluramine, dexfenfluramine, phentermine, or combinations of these medications and compared to unexposed, matched control populations [ 7 8 9 10 11 12 13 14 15 ] . The most recent of these studies found 30% of persons currently taking fenfluramine or dexfenfluramine had mild or greater AR or moderate or greater MR, similar to the very high prevalence reported in older studies [ 15 ] . The only prospective study found a significant, exposure-related increase in the risk of clinically diagnosed valve disease among users of fenfluramine and dexfenfluramine, but not phentermine [ 16 ] .

  • In conclusion, we have estimated risks associated with use of fenfluramine or dexfenfluramine for developing FDA-positive AR and MR after correcting for two major sources of bias.

  • This week, the FDA reported 58 new cases of abnormal heart valves in patients on fen-phen, and the Journal of the American Medical Association reported animal evidence linking both dexfenfluramine and fenfluramine to toxic brain effects.

  • Data provided in this study can be used to estimate the relative contribution of exposure to fenfluramines to overall incidence of echocardiographically defined, FDA-positive AR and MR. Given that approximately 2.5% of the population of the United States had used anorexic prescription drugs (mostly fenfluramine and dexfenfluramine) between 1996 and 1998 [ 30 ] , approximately 32% and 11% of all FDA-positive AR and MR respectively could be attributed to fenfluramine or dexfenfluramine use.

  • In some studies, control subjects were derived from patients assigned to placebo in a formal randomized trial of fenfluramine or dexfenfluramine.


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