Words similar to dexfenfluramine
Example sentences for: dexfenfluramine
How can you use “dexfenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:
In conclusion, we have estimated risks associated with use of fenfluramine or dexfenfluramine for developing FDA-positive AR and MR after correcting for two major sources of bias.
We first evaluated studies reporting echocardiographic prevalence of FDA-positive valvulopathy (mild or greater AR and moderate or greater MR) [ 2 ] among subjects who had taken either fenfluramine or dexfenfluramine (alone or in combination with phentermine) and in matched controls [ 7 8 9 10 11 12 13 14 ] . In most of these studies, echocardiograms were performed after the drugs had been discontinued and were read without knowledge of prior drug exposure by multiple readers (table 1).
We first sought to identify all published studies with echocardiographic assessment of cardiac valve regurgitation in persons exposed to fenfluramine or dexfenfluramine and in suitable controls.
Initial reports of remarkably high prevalence of aortic and mitral regurgitation (AR and MR) as assessed by echocardiography in five separate populations [ 2 ] were subsequently supported by most [ 3 4 5 ] but not all investigators [ 6 ] . These uncontrolled reports were soon followed by a series of studies in which prevalence of echocardiographically-defined AR and MR were assessed in persons who had taken fenfluramine, dexfenfluramine, phentermine, or combinations of these medications and compared to unexposed, matched control populations [ 7 8 9 10 11 12 13 14 15 ] . The most recent of these studies found 30% of persons currently taking fenfluramine or dexfenfluramine had mild or greater AR or moderate or greater MR, similar to the very high prevalence reported in older studies [ 15 ] . The only prospective study found a significant, exposure-related increase in the risk of clinically diagnosed valve disease among users of fenfluramine and dexfenfluramine, but not phentermine [ 16 ] .
This week, the FDA reported 58 new cases of abnormal heart valves in patients on fen-phen, and the Journal of the American Medical Association reported animal evidence linking both dexfenfluramine and fenfluramine to toxic brain effects.
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