Words similar to dexfenfluramine
Example sentences for: dexfenfluramine
How can you use “dexfenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:
In some studies, control subjects were derived from patients assigned to placebo in a formal randomized trial of fenfluramine or dexfenfluramine.
Dr. Hopkins and Dr. Polukoff have been retained as consultants for plaintiff attorneys representing persons who have taken fenfluramine and dexfenfluramine.
Indeed, the most recently published study (which did not suffer from measurement bias) showed a high prevalence (30%) of AR in persons taking fenfluramine or dexfenfluramine at the time of the echocardiogram, similar to the older prevalence studies [ 15 ] . Regarding the potential reversibility of valve dysfunction, great caution must be exercised in assuming any substantial reversal of valvular plaques, as recent pathological studies suggest a progressive nature to these lesions [ 33 ] . Furthermore, limited, early apparent echocardiographic improvement of acute rheumatic carditis has also been recently demonstrated [ 34 ] . The early improvement seen in this setting certainly does not preclude later progression of rheumatic valvular heart disease.
Initial reports of remarkably high prevalence of aortic and mitral regurgitation (AR and MR) as assessed by echocardiography in five separate populations [ 2 ] were subsequently supported by most [ 3 4 5 ] but not all investigators [ 6 ] . These uncontrolled reports were soon followed by a series of studies in which prevalence of echocardiographically-defined AR and MR were assessed in persons who had taken fenfluramine, dexfenfluramine, phentermine, or combinations of these medications and compared to unexposed, matched control populations [ 7 8 9 10 11 12 13 14 15 ] . The most recent of these studies found 30% of persons currently taking fenfluramine or dexfenfluramine had mild or greater AR or moderate or greater MR, similar to the very high prevalence reported in older studies [ 15 ] . The only prospective study found a significant, exposure-related increase in the risk of clinically diagnosed valve disease among users of fenfluramine and dexfenfluramine, but not phentermine [ 16 ] .
We first sought to identify all published studies with echocardiographic assessment of cardiac valve regurgitation in persons exposed to fenfluramine or dexfenfluramine and in suitable controls.
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