Example sentences for: dexfenfluramine

How can you use “dexfenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We first evaluated studies reporting echocardiographic prevalence of FDA-positive valvulopathy (mild or greater AR and moderate or greater MR) [ 2 ] among subjects who had taken either fenfluramine or dexfenfluramine (alone or in combination with phentermine) and in matched controls [ 7 8 9 10 11 12 13 14 ] . In most of these studies, echocardiograms were performed after the drugs had been discontinued and were read without knowledge of prior drug exposure by multiple readers (table 1).

  • Accordingly, our estimates of relative risk associated with fenfluramine or dexfenfluramine use, 19.

  • In conclusion, we have estimated risks associated with use of fenfluramine or dexfenfluramine for developing FDA-positive AR and MR after correcting for two major sources of bias.

  • There were differences in study design and methods (though most were quite similar), fenfluramine or dexfenfluramine doses (though in most studies, doses were similar), additional drugs used, patient characteristics, interval between cessation of therapy and echocardiography, and completeness of follow-up.

  • Indeed, the most recently published study (which did not suffer from measurement bias) showed a high prevalence (30%) of AR in persons taking fenfluramine or dexfenfluramine at the time of the echocardiogram, similar to the older prevalence studies [ 15 ] . Regarding the potential reversibility of valve dysfunction, great caution must be exercised in assuming any substantial reversal of valvular plaques, as recent pathological studies suggest a progressive nature to these lesions [ 33 ] . Furthermore, limited, early apparent echocardiographic improvement of acute rheumatic carditis has also been recently demonstrated [ 34 ] . The early improvement seen in this setting certainly does not preclude later progression of rheumatic valvular heart disease.


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