Words similar to dexamethasone
Example sentences for: dexamethasone
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On the other hand, apoptosis was ruled out as a mechanism to explain the differential down-regulation of CD4 and CD8 by PMA and cAMP, on the grounds of two independent observations: (a) After a maximum of 4.0 hr incubation with either PMA or cAMP+ IBMX the cell viability was the same as the untreated controls (usually between 90-95%); (b) Treatment with dexamethasone, which is a known pro-apoptotic molecule did not have any effects on the expression of either CD4 or CD8 (data not shown) and; (c) As demonstrated earlier in the murine system, TCR engagement of CD4 +CD8 +induces positive selection but not apoptosis [ 12 ]
The mouse homologue of one of the candidate biomarkers, LNC2, has been shown to be regulated at the transcriptional level by dexamethasone in murine cells [ 22 ] . However, there is no published evidence that the human LCN2 gene is likewise dexamethasone-inducible, and there is no description of glucocorticoid-responsive elements in the 5' regulatory region of the human LCN2 gene [ 28 ] . Further, preliminary investigation in our laboratory, using in vitro cultures of purified PBMCs from healthy volunteers, indicates that neither the LCN2 gene nor any of the other 3 transcripts is directly inducible by acute treatment with either SU5416 or dexamethasone (data not shown).
Applying the restriction fingerprints of the above mentioned single clone analysis, we found several genes that were up-regulated in wounds of dexamethasone treated animals.
These studies revealed that the suppression of PP5 expression had no apparent effect on dexamethasone binding, suggesting that PP5 does not affect the formation of the high-affinity ligand binding complex or hormone binding to the GR [ 25].
After two weeks on the high-fat diet, mice from both chow and high-fat diets were either bilaterally adrenalectomized or sham-operated as previously described [ 6 ] . All mice were then given one injection of dexamethasone (45 mg/kg body weight i.p.)
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