Words similar to desorption
Example sentences for: desorption
How can you use “desorption” in a sentence? Here are some example sentences to help you improve your vocabulary:
MALDI-TOF Matrix Assisted Laser Desorption/Ionization Time-of-Flight
Recently, the use of surface-enhanced laser desorption/ionization (SELDI) time-of-flight mass spectrometry profiling of patient serum proteins, combined with advanced data mining algorithms, to detect protein patterns associated with malignancy, has been reported as a promising field of research to achieve the goal of early cancer detection [ 1 2 3 4 5 ] . Several reports have detailed the ability of this proteomic method to diagnose the difference between ovarian cancer [ 6 7 8 ] , prostate cancer [ 9 10 11 12 13 ] , and bladder cancer [ 13 14 ] . Much of the effort in these analyses has focused on the use of a variety of data mining tools such as the evaluation of prostate cancer using peaks in the mass to charge (M/Z) region between 2 K and 40 K combined with boosted decision tree analysis [ 10 ] to try to detect patterns that allow the diagnosis of cancer versus non-cancer.
An early study on DNA microarray hybridization found that hybridization was strongly dependent on the rate constants for DNA adsorption/desorption in the non-probe covered regions of the surface, the two-dimensional diffusion coefficient, and the size of probes and targets and also suggested that sparse probe coverage may provide results equal to or better than those obtained with a surface totally covered with DNA probes [ 19 ] . A theoretical analysis of the kinetics of DNA hybridization demonstrated that diffusion was important in determining the time of required to reach equilibrium and was proportional to the equilibrium binding constant and to the concentration of binding sites [ 20 ] . A recent theoretical and experimental analysis of competitive hybridization in a two-color system demonstrated the need for the hybridization kinetics of the two probes to be the same [ 21 ] . An elegant study on the use of hybridization kinetics to differentiate specific from non-specific binding was recently published [ 22 ] . This study found that the hybridization kinetics for specific and non-specific binding of labeled cRNA to surface-bound oligodeoxyribonucleotides were significantly different, with specific binding requiring longer to reach hybridization equilibrium than non-specific binding.
The CHIP is placed into the mass spectrometer, which takes advantage of the MALDI-TOF (Matrix Assisted Laser Desorption/Ionization Time-of-Flight) mass spectrometry.
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