Example sentences for: desmuslin

How can you use “desmuslin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • DAPC: Dystrophin-associated protein complex; DMN: Desmuslin, SNP: Single-nucleotide polymorphism; IF: Intermediate filament

  • DNA samples isolated from 71 dystrophic and myopathic patients (as described in Table 2) were analyzed by direct sequencing to determine whether the phenotype was the result of a desmuslin mutation.

  • Using the DMN cDNA sequence (AF359284) as a query to blast the public human genome database, we found a genomic clone (AC018999) that included the entire desmuslin coding sequence.

  • The C598T DMN mutation is a good candidate to be a modifier for muscular and/or cardiac phenotypes, considering: (i) the frequency of the mutation in the normal population in the heterozygous as well as homozygous state; and (ii) the key role of desmuslin in connecting the Z-discs to the extracellular matrix.

  • Both desmuslin mRNA and protein are expressed primarily in cardiac and skeletal muscle and the gene encodes a novel intermediate filament (IF) protein of 1253 amino acids.


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