Words similar to dengue

Example sentences for: dengue

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Previously we have reported the successful construction of several dengue virus replicons which replicate intracellularly without the pre-M and E proteins required to form infectious virions, including one replicon which can be expressed from transfected DNA [ 12 ] . Towards the goal of devising a "live" dual vaccine based on only non-structural dengue proteins and heterologous HIV material, we report here that these replicons can be harnessed to express heterologous genes, including HIV gp160 and gp120.
Although we have formally demonstrated expression, not replication, our previous demonstration of the replication [ 12 ] of dengue replicons lacking heterologous material suggests that the replicons described here, which contain heterologous material, are indeed replicating.
However, when we harvested cultures earlier, at 36 hours post transfection with Δpre-M/E-gp160, intact, fluorescing cells were readily found, though the morphology still appeared atypical compared to either that of cultures transfected with wild type dengue virus and dengue replicons [ 12 ] or the Δpre-M/E-gp120 replicon (see Figure 6).
Properly administered, dengue virus replicons expressing HIV epitopes might thus serve as dual vaccines, conferring protection against dengue virus as well as HIV.
In a paper in this month's PLoS Medicine Bernard Cazelles and colleagues looked at the details of the relationship between dengue incidence and El Niño in Thailand.